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Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators.
Peltner LK, Gluthmann L, Börner F, Pace S, Hoffstetter RK, Kretzer C, Bilancia R, Pollastro F, Koeberle A, Appendino G, Rossi A, Newcomer ME, Gilbert NC, Werz O, Jordan PM. Peltner LK, et al. Among authors: appendino g. Cell Chem Biol. 2023 Dec 21;30(12):1508-1524.e7. doi: 10.1016/j.chembiol.2023.08.001. Epub 2023 Aug 29. Cell Chem Biol. 2023. PMID: 37647900
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.
Cullen JK, Yap PY, Ferguson B, Bruce ZC, Koyama M, Handoko H, Hendrawan K, Simmons JL, Brooks KM, Johns J, Wilson ES, de Souza MMA, Broit N, Stewart P, Shelley D, McMahon T, Ogbourne SM, Nguyen TH, Lim YC, Pagani A, Appendino G, Gordon VA, Reddell PW, Boyle GM, Parsons PG. Cullen JK, et al. Among authors: appendino g. J Immunother Cancer. 2024 Apr 24;12(4):e006602. doi: 10.1136/jitc-2022-006602. J Immunother Cancer. 2024. PMID: 38658031 Free PMC article.
Novel Skeletal Rearrangements of the Tigliane Diterpenoid Core.
Maioli C, Amin HIM, Chianese G, Minassi A, Reddell PW, Gaeta S, Taglialatela-Scafati O, Appendino G. Maioli C, et al. Among authors: appendino g. J Nat Prod. 2023 Dec 22;86(12):2685-2690. doi: 10.1021/acs.jnatprod.3c00834. Epub 2023 Nov 22. J Nat Prod. 2023. PMID: 37991924 Free PMC article.
Characteristics and risk factors associated with mortality during the first cycle of prone secondary to ARDS due to SARS-CoV-2 pneumonia.
Gonzalez C, Musso G, Louzan JR, Dominguez JM, Gomez C, Appendino G, Abaca A, Clemente L, Latasa D, Manago M, Lovesio C, Estenssoro E. Gonzalez C, et al. Among authors: appendino g. Med Intensiva (Engl Ed). 2024 Mar;48(3):133-141. doi: 10.1016/j.medine.2023.07.011. Epub 2023 Sep 14. Med Intensiva (Engl Ed). 2024. PMID: 37714730
Scalemic natural products.
Mazzotta S, Rositano V, Senaldi L, Bernardi A, Allegrini P, Appendino G. Mazzotta S, et al. Among authors: appendino g. Nat Prod Rep. 2023 Oct 18;40(10):1647-1671. doi: 10.1039/d3np00014a. Nat Prod Rep. 2023. PMID: 37439042 Free article. Review.
271 results