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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1.
Neurobiol Dis. 2021.
PMID: 34737044
Free article.
AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.
Eketjäll S, Janson J, Jeppsson F, Svanhagen A, Kolmodin K, Gustavsson S, Radesäter AC, Eliason K, Briem S, Appelkvist P, Niva C, Berg AL, Karlström S, Swahn BM, Fälting J.
Eketjäll S, et al. Among authors: appelkvist p.
J Neurosci. 2013 Jun 12;33(24):10075-84. doi: 10.1523/JNEUROSCI.1165-13.2013.
J Neurosci. 2013.
PMID: 23761903
Free PMC article.
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Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI.
Wang FH, Appelkvist P, Klason T, Gissberg O, Bogstedt A, Eliason K, Martinsson S, Briem S, Andersson A, Visser SA, Ivarsson M, Lindberg M, Agerman K, Sandin J.
Wang FH, et al. Among authors: appelkvist p.
Eur J Neurosci. 2012 Nov;36(9):3165-72. doi: 10.1111/j.1460-9568.2012.08258.x. Epub 2012 Sep 10.
Eur J Neurosci. 2012.
PMID: 22958226
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Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition.
Parkinson J, Ploeger B, Appelkvist P, Bogstedt A, Dillner Bergstedt K, Eketjäll S, Visser SA.
Parkinson J, et al. Among authors: appelkvist p.
Pharmacol Res Perspect. 2013 Dec;1(2):e00012. doi: 10.1002/prp2.12. Epub 2013 Dec 5.
Pharmacol Res Perspect. 2013.
PMID: 25505567
Free PMC article.
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Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β.
Henderson SJ, Andersson C, Narwal R, Janson J, Goldschmidt TJ, Appelkvist P, Bogstedt A, Steffen AC, Haupts U, Tebbe J, Freskgård PO, Jermutus L, Burrell M, Fowler SB, Webster CI.
Henderson SJ, et al. Among authors: appelkvist p.
Brain. 2014 Feb;137(Pt 2):553-64. doi: 10.1093/brain/awt308. Epub 2013 Nov 20.
Brain. 2014.
PMID: 24259408
Free PMC article.
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Characterization of the effect of a novel γ-secretase modulator on Aβ: a clinically translatable model.
Portelius E, Appelkvist P, Stromberg K, Hoglund K.
Portelius E, et al. Among authors: appelkvist p.
Curr Pharm Des. 2014;20(15):2484-90. doi: 10.2174/13816128113199990499.
Curr Pharm Des. 2014.
PMID: 23859556
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Characterization of beta2-microglobulin in a primitive fish, the Siberian sturgeon (Acipenser baeri).
Lundqvist ML, Appelkvist P, Hermsen T, Pilström L, Stet RJ.
Lundqvist ML, et al. Among authors: appelkvist p.
Immunogenetics. 1999 Oct;50(1-2):79-83. doi: 10.1007/s002510050690.
Immunogenetics. 1999.
PMID: 10541811
No abstract available.
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