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Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors.
Grosskopf AK, Labanieh L, Klysz DD, Roth GA, Xu P, Adebowale O, Gale EC, Jons CK, Klich JH, Yan J, Maikawa CL, Correa S, Ou BS, d'Aquino AI, Cochran JR, Chaudhuri O, Mackall CL, Appel EA. Grosskopf AK, et al. Among authors: appel ea. Sci Adv. 2022 Apr 8;8(14):eabn8264. doi: 10.1126/sciadv.abn8264. Epub 2022 Apr 8. Sci Adv. 2022. PMID: 35394838 Free PMC article.
Use of a supramolecular polymeric hydrogel as an effective post-operative pericardial adhesion barrier.
Stapleton LM, Steele AN, Wang H, Lopez Hernandez H, Yu AC, Paulsen MJ, Smith AAA, Roth GA, Thakore AD, Lucian HJ, Totherow KP, Baker SW, Tada Y, Farry JM, Eskandari A, Hironaka CE, Jaatinen KJ, Williams KM, Bergamasco H, Marschel C, Chadwick B, Grady F, Ma M, Appel EA, Woo YJ. Stapleton LM, et al. Among authors: appel ea. Nat Biomed Eng. 2019 Aug;3(8):611-620. doi: 10.1038/s41551-019-0442-z. Epub 2019 Aug 7. Nat Biomed Eng. 2019. PMID: 31391596
Multi-phase catheter-injectable hydrogel enables dual-stage protein-engineered cytokine release to mitigate adverse left ventricular remodeling following myocardial infarction in a small animal model and a large animal model.
Steele AN, Paulsen MJ, Wang H, Stapleton LM, Lucian HJ, Eskandari A, Hironaka CE, Farry JM, Baker SW, Thakore AD, Jaatinen KJ, Tada Y, Hollander MJ, Williams KM, Seymour AJ, Totherow KP, Yu AC, Cochran JR, Appel EA, Woo YJ. Steele AN, et al. Among authors: appel ea. Cytokine. 2020 Mar;127:154974. doi: 10.1016/j.cyto.2019.154974. Epub 2020 Jan 21. Cytokine. 2020. PMID: 31978642
A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs.
Maikawa CL, Smith AAA, Zou L, Roth GA, Gale EC, Stapleton LM, Baker SW, Mann JL, Yu AC, Correa S, Grosskopf AK, Liong CS, Meis CM, Chan D, Troxell M, Maahs DM, Buckingham BA, Webber MJ, Appel EA. Maikawa CL, et al. Among authors: appel ea. Nat Biomed Eng. 2020 May;4(5):507-517. doi: 10.1038/s41551-020-0555-4. Epub 2020 May 11. Nat Biomed Eng. 2020. PMID: 32393892 Free PMC article.
104 results