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NA1-115-7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes.
Daressy F, Séguy L, Favre L, Corvaisier S, Apel C, Groo AC, Litaudon M, Dumontet V, Malzert-Fréon A, Desrat S, Roussi F, Robert A, Wiels J. Daressy F, et al. Among authors: apel c. Biomed Pharmacother. 2022 Oct;154:113546. doi: 10.1016/j.biopha.2022.113546. Epub 2022 Aug 18. Biomed Pharmacother. 2022. PMID: 35988426 Free article.
Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.
Allouche N, Apel C, Martin MT, Dumontet V, Guéritte F, Litaudon M. Allouche N, et al. Among authors: apel c. Phytochemistry. 2009 Mar;70(4):546-53. doi: 10.1016/j.phytochem.2009.01.012. Epub 2009 Feb 27. Phytochemistry. 2009. PMID: 19251287
Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.
Olivon F, Allard PM, Koval A, Righi D, Genta-Jouve G, Neyts J, Apel C, Pannecouque C, Nothias LF, Cachet X, Marcourt L, Roussi F, Katanaev VL, Touboul D, Wolfender JL, Litaudon M. Olivon F, et al. Among authors: apel c. ACS Chem Biol. 2017 Oct 20;12(10):2644-2651. doi: 10.1021/acschembio.7b00413. Epub 2017 Sep 15. ACS Chem Biol. 2017. PMID: 28829118
108 results