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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Budu-Aggrey A, Kilanowski A, Sobczyk MK; 23andMe Research Team; Shringarpure SS, Mitchell R, Reis K, Reigo A; Estonian Biobank Research Team; Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-Navais P, Flatley C, Espuela-Ortiz A, Herrera-Luis E, Lominchar JVT, Bork-Jensen J, Marenholz I, Arnau-Soler A, Jeong A, Fawcett KA, Baurecht H, Rodriguez E, Alves AC, Kumar A, Sleiman PM, Chang X, Medina-Gomez C, Hu C, Xu CJ, Qi C, El-Heis S, Titcombe P, Antoun E, Fadista J, Wang CA, Thiering E, Wu B, Kress S, Kothalawala DM, Kadalayil L, Duan J, Zhang H, Hadebe S, Hoffmann T, Jorgenson E, Choquet H, Risch N, Njølstad P, Andreassen OA, Johansson S, Almqvist C, Gong T, Ullemar V, Karlsson R, Magnusson PKE, Szwajda A, Burchard EG, Thyssen JP, Hansen T, Kårhus LL, Dantoft TM, Jeanrenaud ACSN, Ghauri A, Arnold A, Homuth G, Lau S, Nöthen MM, Hübner N, Imboden M, Visconti A, Falchi M, Bataille V, Hysi P, Ballardini N, Boomsma DI, Hottenga JJ, Müller-Nurasyid M, Ahluwalia TS, Stokholm J, Chawes B, Schoos AM, Esplugues A, Bustamante M, Raby B, Arshad S, German C, Esko T, Milani LA, Metspalu A, Terao C, Abuabara K, Løset M, Hveem K, Jacobsson B, Pino-Yanes M, Strachan DP, Grarup N, Linne… See abstract for full author list ➔ Budu-Aggrey A, et al. Among authors: antoun e. Nat Commun. 2023 Oct 4;14(1):6172. doi: 10.1038/s41467-023-41180-2. Nat Commun. 2023. PMID: 37794016 Free PMC article.
DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.
Barton SJ, Ngo S, Costello P, Garratt E, El-Heis S, Antoun E, Clarke-Harris R, Murray R, Bhatt T, Burdge G, Cooper C, Inskip H, van der Beek EM, Sheppard A, Godfrey KM, Lillycrop KA; EpiGen Consortium. Barton SJ, et al. Among authors: antoun e. Clin Exp Allergy. 2017 Dec;47(12):1599-1608. doi: 10.1111/cea.12988. Epub 2017 Aug 31. Clin Exp Allergy. 2017. PMID: 28756630 Free PMC article.
Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities.
Migliavacca E, Tay SKH, Patel HP, Sonntag T, Civiletto G, McFarlane C, Forrester T, Barton SJ, Leow MK, Antoun E, Charpagne A, Seng Chong Y, Descombes P, Feng L, Francis-Emmanuel P, Garratt ES, Giner MP, Green CO, Karaz S, Kothandaraman N, Marquis J, Metairon S, Moco S, Nelson G, Ngo S, Pleasants T, Raymond F, Sayer AA, Ming Sim C, Slater-Jefferies J, Syddall HE, Fang Tan P, Titcombe P, Vaz C, Westbury LD, Wong G, Yonghui W, Cooper C, Sheppard A, Godfrey KM, Lillycrop KA, Karnani N, Feige JN. Migliavacca E, et al. Among authors: antoun e. Nat Commun. 2019 Dec 20;10(1):5808. doi: 10.1038/s41467-019-13694-1. Nat Commun. 2019. PMID: 31862890 Free PMC article.
Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.
Antoun E, Kitaba NT, Titcombe P, Dalrymple KV, Garratt ES, Barton SJ, Murray R, Seed PT, Holbrook JD, Kobor MS, Lin DT, MacIsaac JL, Burdge GC, White SL, Poston L, Godfrey KM, Lillycrop KA; UPBEAT Consortium. Antoun E, et al. PLoS Med. 2020 Nov 5;17(11):e1003229. doi: 10.1371/journal.pmed.1003229. eCollection 2020 Nov. PLoS Med. 2020. PMID: 33151971 Free PMC article. Clinical Trial.
DNA methylation signatures in cord blood associated with birthweight are enriched for dmCpGs previously associated with maternal hypertension or pre-eclampsia, smoking and folic acid intake.
Antoun E, Titcombe P, Dalrymple K, Kitaba NT, Barton SJ, Flynn A, Murray R, Garratt ES, Seed PT, White SL, Cooper C, Inskip HM, Hanson M, Poston L, Godfrey KM, Lillycrop KA; UPBEAT Consortium/EpiGen Consortium. Antoun E, et al. Epigenetics. 2022 Apr;17(4):405-421. doi: 10.1080/15592294.2021.1908706. Epub 2021 Apr 28. Epigenetics. 2022. PMID: 33784941 Free PMC article.
Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years.
Murray R, Kitaba N, Antoun E, Titcombe P, Barton S, Cooper C, Inskip HM, Burdge GC, Mahon PA, Deanfield J, Halcox JP, Ellins EA, Bryant J, Peebles C, Lillycrop K, Godfrey KM, Hanson MA; EpiGen Consortium. Murray R, et al. Among authors: antoun e. Hypertension. 2021 Sep;78(3):787-800. doi: 10.1161/HYPERTENSIONAHA.121.17396. Epub 2021 Jul 19. Hypertension. 2021. PMID: 34275334 Free PMC article.
Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).
Antoun E, Garratt ES, Taddei A, Burton MA, Barton SJ, Titcombe P, Westbury LD, Baczynska A, Migliavacca E, Feige JN, Sydall HE, Dennison E, Dodds R, Roberts HC, Richardson P, Sayer AA, Shaw S, Cooper C, Holbrook JD, Patel HP, Godfrey KM, Lillycrop KA; EpiGen Global Research Consortium. Antoun E, et al. J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):240-253. doi: 10.1002/jcsm.12876. Epub 2021 Dec 4. J Cachexia Sarcopenia Muscle. 2022. PMID: 34862756 Free PMC article.
Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle.
Burton MA, Antoun E, Garratt ES, Westbury L, Baczynska A, Dennison EM, Harvey NC, Cooper C, Patel HP, Godfrey KM, Lillycrop KA; EpiGen Global Research Consortium. Burton MA, et al. Among authors: antoun e. J Cachexia Sarcopenia Muscle. 2023 Aug;14(4):1762-1774. doi: 10.1002/jcsm.13255. Epub 2023 May 18. J Cachexia Sarcopenia Muscle. 2023. PMID: 37199333 Free PMC article.
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