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Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer.
Clin Cancer Res. 2021 Nov 1;27(21):5961-5978. doi: 10.1158/1078-0432.CCR-21-0986. Epub 2021 Aug 18.
Clin Cancer Res. 2021.
PMID: 34407972
Free PMC article.
Clinical Trial.
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial.
Sarker D, Plummer R, Meyer T, Sodergren MH, Basu B, Chee CE, Huang KW, Palmer DH, Ma YT, Evans TRJ, Spalding DRC, Pai M, Sharma R, Pinato DJ, Spicer J, Hunter S, Kwatra V, Nicholls JP, Collin D, Nutbrown R, Glenny H, Fairbairn S, Reebye V, Voutila J, Dorman S, Andrikakou P, Lloyd P, Felstead S, Vasara J, Habib R, Wood C, Saetrom P, Huber HE, Blakey DC, Rossi JJ, Habib N.
Sarker D, et al. Among authors: andrikakou p.
Clin Cancer Res. 2020 Aug 1;26(15):3936-3946. doi: 10.1158/1078-0432.CCR-20-0414. Epub 2020 May 1.
Clin Cancer Res. 2020.
PMID: 32357963
Free article.
Clinical Trial.
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Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer.
Voutila J, Reebye V, Roberts TC, Protopapa P, Andrikakou P, Blakey DC, Habib R, Huber H, Saetrom P, Rossi JJ, Habib NA.
Voutila J, et al. Among authors: andrikakou p.
Mol Ther. 2017 Dec 6;25(12):2705-2714. doi: 10.1016/j.ymthe.2017.07.018. Epub 2017 Aug 4.
Mol Ther. 2017.
PMID: 28882451
Free PMC article.
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Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer.
Reebye V, Huang KW, Lin V, Jarvis S, Cutilas P, Dorman S, Ciriello S, Andrikakou P, Voutila J, Saetrom P, Mintz PJ, Reccia I, Rossi JJ, Huber H, Habib R, Kostomitsopoulos N, Blakey DC, Habib NA.
Reebye V, et al. Among authors: andrikakou p.
Oncogene. 2018 Jun;37(24):3216-3228. doi: 10.1038/s41388-018-0126-2. Epub 2018 Mar 7.
Oncogene. 2018.
PMID: 29511346
Free PMC article.
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Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC.
Yoon S, Huang KW, Andrikakou P, Vasconcelos D, Swiderski P, Reebye V, Sodergren M, Habib N, Rossi JJ.
Yoon S, et al. Among authors: andrikakou p.
Mol Ther Nucleic Acids. 2019 Dec 6;18:142-154. doi: 10.1016/j.omtn.2019.08.017. Epub 2019 Aug 22.
Mol Ther Nucleic Acids. 2019.
PMID: 31546149
Free PMC article.
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Enhancing SIRT1 Gene Expression Using Small Activating RNAs: A Novel Approach for Reversing Metabolic Syndrome.
Andrikakou P, Reebye V, Vasconcelos D, Yoon S, Voutila J, George AJT, Swiderski P, Habib R, Catley M, Blakey D, Habib NA, Rossi JJ, Huang KW.
Andrikakou P, et al.
Nucleic Acid Ther. 2022 Dec;32(6):486-496. doi: 10.1089/nat.2021.0115. Epub 2022 Jul 27.
Nucleic Acid Ther. 2022.
PMID: 35895511
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On the behaviour of lung tissue under tension and compression.
Andrikakou P, Vickraman K, Arora H.
Andrikakou P, et al.
Sci Rep. 2016 Nov 7;6:36642. doi: 10.1038/srep36642.
Sci Rep. 2016.
PMID: 27819358
Free PMC article.
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