Andrew M. Fry - Search Results

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The mesenchymal morphology of cells expressing the EML4-ALK V3 oncogene is dependent on phosphorylation of Eg5 by NEK7.

Pashley SL, Papageorgiou S, O'Regan L, Barone G, Robinson SW, Lucken K, Straatman KR, Roig J, Fry AM. Pashley SL, et al. Among authors: fry am. J Biol Chem. 2024 Mar 6;300(5):107144. doi: 10.1016/j.jbc.2024.107144. Online ahead of print. J Biol Chem. 2024. PMID: 38458397 Free PMC article.

BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms.

Singh A, Busacca S, Gaba A, Sheaff M, Poile C, Nakas A, Dzialo J, Bzura A, Dawson AG, Fennell DA, Fry AM. Singh A, et al. Among authors: fry am. Oncogene. 2023 Feb;42(8):572-585. doi: 10.1038/s41388-022-02577-3. Epub 2022 Dec 22. Oncogene. 2023. PMID: 36550359 Free PMC article.

Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity and cellular functions.

Malki I, Liepina I, Kogelnik N, Watmuff H, Robinson S, Lightfoot A, Gonchar O, Bottrill A, Fry AM, Dominguez C. Malki I, et al. Among authors: fry am. Nucleic Acids Res. 2022 Dec 9;50(22):13045-13062. doi: 10.1093/nar/gkac1181. Nucleic Acids Res. 2022. PMID: 36537190 Free PMC article.

Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer.

Papageorgiou S, Pashley SL, O'Regan L, Khan S, Bayliss R, Fry AM. Papageorgiou S, et al. Among authors: fry am. Cancers (Basel). 2022 Jul 15;14(14):3452. doi: 10.3390/cancers14143452. Cancers (Basel). 2022. PMID: 35884511 Free PMC article. Review.

EML4-ALK Variant 3 Promotes Mitotic Errors and Spindle Assembly Checkpoint Deficiency Leading to Increased Microtubule Poison Sensitivity.

Lucken K, O'Regan L, Choi J, Sampson J, Pashley SL, Bayliss R, Khan S, Fry AM. Lucken K, et al. Among authors: fry am. Mol Cancer Res. 2022 Jun 3;20(6):854-866. doi: 10.1158/1541-7786.MCR-21-1010. Mol Cancer Res. 2022. PMID: 35656694 Free PMC article.

A Polytherapy Strategy Using Vincristine and ALK Inhibitors to Sensitise EML4-ALK-Positive NSCLC.

Sampson J, Ju HM, Song JY, Fry AM, Bayliss R, Choi J. Sampson J, et al. Among authors: fry am. Cancers (Basel). 2022 Feb 2;14(3):779. doi: 10.3390/cancers14030779. Cancers (Basel). 2022. PMID: 35159046 Free PMC article.

Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes.

Hindul NL, Jhita A, Oprea DG, Hussain TA, Gonchar O, Campillo MAM, O'Regan L, Kanemaki MT, Fry AM, Hirota K, Tanaka K. Hindul NL, et al. Among authors: fry am. Biol Open. 2022 Feb 15;11(2):bio059056. doi: 10.1242/bio.059056. Epub 2022 Feb 16. Biol Open. 2022. PMID: 35067715 Free PMC article.

Phase-separated foci of EML4-ALK facilitate signalling and depend upon an active kinase conformation.

Sampson J, Richards MW, Choi J, Fry AM, Bayliss R. Sampson J, et al. Among authors: fry am. EMBO Rep. 2021 Dec 6;22(12):e53693. doi: 10.15252/embr.202153693. Epub 2021 Oct 18. EMBO Rep. 2021. PMID: 34661367 Free PMC article.

2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.

Matheson CJ, Coxon CR, Bayliss R, Boxall K, Carbain B, Fry AM, Hardcastle IR, Harnor SJ, Mas-Droux C, Newell DR, Richards MW, Sivaprakasam M, Turner D, Griffin RJ, Golding BT, Cano C. Matheson CJ, et al. Among authors: fry am. RSC Med Chem. 2020 May 22;11(6):707-731. doi: 10.1039/d0md00074d. eCollection 2020 Jun 1. RSC Med Chem. 2020. PMID: 33479670 Free PMC article.

BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma.

Busacca S, O'Regan L, Singh A, Sharkey AJ, Dawson AG, Dzialo J, Parsons A, Kumar N, Schunselaar LM, Guppy N, Nakas A, Sheaff M, Mansfield AS, Janes SM, Baas P, Fry AM, Fennell DA. Busacca S, et al. Among authors: fry am. Mol Cancer Ther. 2021 Feb;20(2):379-388. doi: 10.1158/1535-7163.MCT-20-0363. Epub 2020 Nov 6. Mol Cancer Ther. 2021. PMID: 33158996

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