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Splicing-directed therapy in a new mouse model of human accelerated aging.
Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C. Osorio FG, et al. Among authors: andres v. Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847. Sci Transl Med. 2011. PMID: 22030750
Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment.
Villa-Bellosta R, Rivera-Torres J, Osorio FG, Acín-Pérez R, Enriquez JA, López-Otín C, Andrés V. Villa-Bellosta R, et al. Among authors: andres v. Circulation. 2013 Jun 18;127(24):2442-51. doi: 10.1161/CIRCULATIONAHA.112.000571. Epub 2013 May 20. Circulation. 2013. PMID: 23690466
Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.
Rivera-Torres J, Acín-Perez R, Cabezas-Sánchez P, Osorio FG, Gonzalez-Gómez C, Megias D, Cámara C, López-Otín C, Enríquez JA, Luque-García JL, Andrés V. Rivera-Torres J, et al. Among authors: andres v. J Proteomics. 2013 Oct 8;91:466-77. doi: 10.1016/j.jprot.2013.08.008. Epub 2013 Aug 20. J Proteomics. 2013. PMID: 23969228
Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.
González-Granado JM, Silvestre-Roig C, Rocha-Perugini V, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JMP, López-Otín C, Sánchez-Madrid F, Andrés V. González-Granado JM, et al. Among authors: andres v. Sci Signal. 2014 Apr 22;7(322):ra37. doi: 10.1126/scisignal.2004872. Sci Signal. 2014. PMID: 24757177 Free PMC article.
Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.
Rivera-Torres J, Calvo CJ, Llach A, Guzmán-Martínez G, Caballero R, González-Gómez C, Jiménez-Borreguero LJ, Guadix JA, Osorio FG, López-Otín C, Herraiz-Martínez A, Cabello N, Vallmitjana A, Benítez R, Gordon LB, Jalife J, Pérez-Pomares JM, Tamargo J, Delpón E, Hove-Madsen L, Filgueiras-Rama D, Andrés V. Rivera-Torres J, et al. Among authors: andres v. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7250-E7259. doi: 10.1073/pnas.1603754113. Epub 2016 Oct 31. Proc Natl Acad Sci U S A. 2016. PMID: 27799555 Free PMC article.
Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome.
Hamczyk MR, Villa-Bellosta R, Gonzalo P, Andrés-Manzano MJ, Nogales P, Bentzon JF, López-Otín C, Andrés V. Hamczyk MR, et al. Among authors: andres v, andres manzano mj. Circulation. 2018 Jul 17;138(3):266-282. doi: 10.1161/CIRCULATIONAHA.117.030856. Epub 2018 Feb 28. Circulation. 2018. PMID: 29490993 Free PMC article.
The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function.
Caravia XM, Fanjul V, Oliver E, Roiz-Valle D, Morán-Álvarez A, Desdín-Micó G, Mittelbrunn M, Cabo R, Vega JA, Rodríguez F, Fueyo A, Gómez M, Lobo-González M, Bueno H, Velasco G, Freije JMP, Andrés V, Ibáñez B, Ugalde AP, López-Otín C. Caravia XM, et al. Among authors: andres v. PLoS Biol. 2018 Oct 22;16(10):e2006247. doi: 10.1371/journal.pbio.2006247. eCollection 2018 Oct. PLoS Biol. 2018. PMID: 30346946 Free PMC article.
224 results