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High affinity CXCR4 inhibitors generated by linking low affinity peptides.
Zhang C, Huang LS, Zhu R, Meng Q, Zhu S, Xu Y, Zhang H, Fang X, Zhang X, Zhou J, Schooley RT, Yang X, Huang Z, An J. Zhang C, et al. Among authors: an j. Eur J Med Chem. 2019 Jun 15;172:174-185. doi: 10.1016/j.ejmech.2019.03.056. Epub 2019 Apr 1. Eur J Med Chem. 2019. PMID: 30978562 Free PMC article.
Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors.
Choi WT, Tian S, Dong CZ, Kumar S, Liu D, Madani N, An J, Sodroski JG, Huang Z. Choi WT, et al. Among authors: an j. J Virol. 2005 Dec;79(24):15398-404. doi: 10.1128/JVI.79.24.15398-15404.2005. J Virol. 2005. PMID: 16306611 Free PMC article.
The chemokine receptor CXCR4 plays an important role as the receptor for the normal physiological function of stromal cell-derived factor 1alpha (SDF-1alpha) and the coreceptor for the entry of human immunodeficiency virus type 1 (HIV-1) into the cell. In a recent work (S. …
The chemokine receptor CXCR4 plays an important role as the receptor for the normal physiological function of stromal cell-derived fa …
5,649 results