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Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle.
Chursa U, Nuñez-Durán E, Cansby E, Amrutkar M, Sütt S, Ståhlman M, Olsson BM, Borén J, Johansson ME, Bäckhed F, Johansson BR, Sihlbom C, Mahlapuu M. Chursa U, et al. Among authors: amrutkar m. Diabetologia. 2017 Mar;60(3):553-567. doi: 10.1007/s00125-016-4171-5. Epub 2016 Dec 16. Diabetologia. 2017. PMID: 27981357 Free PMC article.
STK25 is a critical determinant in nonalcoholic steatohepatitis.
Amrutkar M, Chursa U, Kern M, Nuñez-Durán E, Ståhlman M, Sütt S, Borén J, Johansson BR, Marschall HU, Blüher M, Mahlapuu M. Amrutkar M, et al. FASEB J. 2016 Oct;30(10):3628-3643. doi: 10.1096/fj.201600562R. Epub 2016 Jul 15. FASEB J. 2016. PMID: 27421788
The study provides evidence for multiple roles of STK25 in NASH pathogenesis and future investigations to address the potential therapeutic relevance of pharmacological STK25 inhibitors in prevention and treatment of NASH are warranted.-Amrutkar, M., Chursa, U., Ker …
The study provides evidence for multiple roles of STK25 in NASH pathogenesis and future investigations to address the potential therapeutic …
Pancreatic Cancer Chemoresistance to Gemcitabine.
Amrutkar M, Gladhaug IP. Amrutkar M, et al. Cancers (Basel). 2017 Nov 16;9(11):157. doi: 10.3390/cancers9110157. Cancers (Basel). 2017. PMID: 29144412 Free PMC article. Review.
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