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STK25 is a critical determinant in nonalcoholic steatohepatitis.
Amrutkar M, Chursa U, Kern M, Nuñez-Durán E, Ståhlman M, Sütt S, Borén J, Johansson BR, Marschall HU, Blüher M, Mahlapuu M. Amrutkar M, et al. FASEB J. 2016 Oct;30(10):3628-3643. doi: 10.1096/fj.201600562R. Epub 2016 Jul 15. FASEB J. 2016. PMID: 27421788
The study provides evidence for multiple roles of STK25 in NASH pathogenesis and future investigations to address the potential therapeutic relevance of pharmacological STK25 inhibitors in prevention and treatment of NASH are warranted.-Amrutkar, M., Chursa, U., Ker …
The study provides evidence for multiple roles of STK25 in NASH pathogenesis and future investigations to address the potential therapeutic …
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle.
Chursa U, Nuñez-Durán E, Cansby E, Amrutkar M, Sütt S, Ståhlman M, Olsson BM, Borén J, Johansson ME, Bäckhed F, Johansson BR, Sihlbom C, Mahlapuu M. Chursa U, et al. Among authors: amrutkar m. Diabetologia. 2017 Mar;60(3):553-567. doi: 10.1007/s00125-016-4171-5. Epub 2016 Dec 16. Diabetologia. 2017. PMID: 27981357 Free PMC article.
STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.
Sütt S, Cansby E, Paul A, Amrutkar M, Nuñez-Durán E, Kulkarni NM, Ståhlman M, Borén J, Laurencikiene J, Howell BW, Enerbäck S, Mahlapuu M. Sütt S, et al. Among authors: amrutkar m. J Endocrinol. 2018 Sep;238(3):187-202. doi: 10.1530/JOE-18-0182. Epub 2018 May 24. J Endocrinol. 2018. PMID: 29794231
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.
Cansby E, Nuñez-Durán E, Magnusson E, Amrutkar M, Booten SL, Kulkarni NM, Svensson LT, Borén J, Marschall HU, Aghajan M, Mahlapuu M. Cansby E, et al. Among authors: amrutkar m. Cell Mol Gastroenterol Hepatol. 2019;7(3):597-618. doi: 10.1016/j.jcmgh.2018.12.004. Epub 2018 Dec 19. Cell Mol Gastroenterol Hepatol. 2019. PMID: 30576769 Free PMC article.
Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans.
Cansby E, Kulkarni NM, Magnusson E, Kurhe Y, Amrutkar M, Nerstedt A, Ståhlman M, Sihlbom C, Marschall HU, Borén J, Blüher M, Mahlapuu M. Cansby E, et al. Among authors: amrutkar m. FASEB J. 2019 Sep;33(9):9974-9989. doi: 10.1096/fj.201900356RR. Epub 2019 Jun 7. FASEB J. 2019. PMID: 31173506
Our findings highlight MST3 as a potential drug target for the prevention and treatment of NASH and related complex metabolic diseases.-Cansby, E., Kulkarni, N. M., Magnusson, E., Kurhe, Y., Amrutkar, M., Nerstedt, A., Stahlman, M., Sihlbom, C., Marsch …
Our findings highlight MST3 as a potential drug target for the prevention and treatment of NASH and related complex metabolic diseases.-Cans …
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