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In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK. Brown CS, et al. Among authors: amarasinghe gk. J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1. J Mol Biol. 2014. PMID: 24495995 Free PMC article.
Real-world COVID-19 vaccine effectiveness against the Omicron BA.2 variant in a SARS-CoV-2 infection-naive population.
Lau JJ, Cheng SMS, Leung K, Lee CK, Hachim A, Tsang LCH, Yam KWH, Chaothai S, Kwan KKH, Chai ZYH, Lo THK, Mori M, Wu C, Valkenburg SA, Amarasinghe GK, Lau EHY, Hui DSC, Leung GM, Peiris M, Wu JT. Lau JJ, et al. Among authors: amarasinghe gk. Nat Med. 2023 Feb;29(2):348-357. doi: 10.1038/s41591-023-02219-5. Epub 2023 Jan 18. Nat Med. 2023. PMID: 36652990 Free PMC article.
Structure of the Ebola VP35 interferon inhibitory domain.
Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK. Leung DW, et al. Among authors: amarasinghe gk. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):411-6. doi: 10.1073/pnas.0807854106. Epub 2009 Jan 2. Proc Natl Acad Sci U S A. 2009. PMID: 19122151 Free PMC article.
Evasion of interferon responses by Ebola and Marburg viruses.
Basler CF, Amarasinghe GK. Basler CF, et al. Among authors: amarasinghe gk. J Interferon Cytokine Res. 2009 Sep;29(9):511-20. doi: 10.1089/jir.2009.0076. J Interferon Cytokine Res. 2009. PMID: 19694547 Free PMC article. Review.
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK. Leung DW, et al. Among authors: amarasinghe gk. Nat Struct Mol Biol. 2010 Feb;17(2):165-72. doi: 10.1038/nsmb.1765. Epub 2010 Jan 17. Nat Struct Mol Biol. 2010. PMID: 20081868 Free PMC article.
Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.
Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK. Leung DW, et al. Among authors: amarasinghe gk. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jun 1;66(Pt 6):689-92. doi: 10.1107/S1744309110013266. Epub 2010 May 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20516601 Free PMC article.
129 results