Amaral MD - Search Results

1

Precision medicine for rare diseases: The times they are A-Changin'.

Amaral MD. Amaral MD. Curr Opin Pharmacol. 2022 Apr;63:102201. doi: 10.1016/j.coph.2022.102201. Epub 2022 Mar 4. Curr Opin Pharmacol. 2022. PMID: 35255452 Review.

2

Targeting CFTR: how to treat cystic fibrosis by CFTR-repairing therapies.

Amaral MD. Amaral MD. Curr Drug Targets. 2011 May;12(5):683-93. doi: 10.2174/138945011795378586. Curr Drug Targets. 2011. PMID: 21039334 Review.

3

New pharmacological approaches for cystic fibrosis: promises, progress, pitfalls.

Bell SC, De Boeck K, Amaral MD. Bell SC, et al. Among authors: amaral md. Pharmacol Ther. 2015 Jan;145:19-34. doi: 10.1016/j.pharmthera.2014.06.005. Epub 2014 Jun 14. Pharmacol Ther. 2015. PMID: 24932877

4

Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients.

Amaral MD. Amaral MD. J Intern Med. 2015 Feb;277(2):155-166. doi: 10.1111/joim.12314. J Intern Med. 2015. PMID: 25266997 Free article. Review.

5

Progress in therapies for cystic fibrosis.

De Boeck K, Amaral MD. De Boeck K, et al. Among authors: amaral md. Lancet Respir Med. 2016 Aug;4(8):662-674. doi: 10.1016/S2213-2600(16)00023-0. Epub 2016 Apr 1. Lancet Respir Med. 2016. PMID: 27053340 Review.

6

mRNA-based detection of rare CFTR mutations improves genetic diagnosis of cystic fibrosis in populations with high genetic heterogeneity.

Felício V, Ramalho AS, Igreja S, Amaral MD. Felício V, et al. Among authors: amaral md. Clin Genet. 2017 Mar;91(3):476-481. doi: 10.1111/cge.12802. Epub 2016 Jun 1. Clin Genet. 2017. PMID: 27174726

7

Characterization of the mechanism of action of RDR01752, a novel corrector of F508del-CFTR.

Lopes-Pacheco M, Silva IAL, Turner MJ, Carlile GW, Sondo E, Thomas DY, Pedemonte N, Hanrahan JW, Amaral MD. Lopes-Pacheco M, et al. Among authors: amaral md. Biochem Pharmacol. 2020 Oct;180:114133. doi: 10.1016/j.bcp.2020.114133. Epub 2020 Jul 3. Biochem Pharmacol. 2020. PMID: 32628927

8

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G.

Silva IAL, Doušová T, Ramalho S, Centeio R, Clarke LA, Railean V, Botelho HM, Holubová A, Valášková I, Yeh JT, Hwang TC, Farinha CM, Kunzelmann K, Amaral MD. Silva IAL, et al. Among authors: amaral md. Biochim Biophys Acta Mol Basis Dis. 2020 Nov 1;1866(11):165905. doi: 10.1016/j.bbadis.2020.165905. Epub 2020 Jul 28. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32730979 Free PMC article.

9

How to determine the mechanism of action of CFTR modulator compounds: A gateway to theranostics.

Amaral MD. Amaral MD. Eur J Med Chem. 2021 Jan 15;210:112989. doi: 10.1016/j.ejmech.2020.112989. Epub 2020 Nov 5. Eur J Med Chem. 2021. PMID: 33190956 Review.

10

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids.

Silva IAL, Railean V, Duarte A, Amaral MD. Silva IAL, et al. Among authors: amaral md. J Pers Med. 2021 May 16;11(5):421. doi: 10.3390/jpm11050421. J Pers Med. 2021. PMID: 34065744 Free PMC article.

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