Altamura S - Search Results

1

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase.

De Francesco R, Tomei L, Altamura S, Summa V, Migliaccio G. De Francesco R, et al. Among authors: altamura s. Antiviral Res. 2003 Mar;58(1):1-16. doi: 10.1016/s0166-3542(03)00028-7. Antiviral Res. 2003. PMID: 12719002 Review.

2

A scintillation proximity active site binding assay for the hepatitis C virus serine protease.

Steinkühler C, Biasiol G, Cerretani M, Di Renzo L, Brunetti M, Ingallinella P, De Francesco R, Altamura S. Steinkühler C, et al. Among authors: altamura s. Anal Biochem. 2002 Aug 1;307(1):99-104. doi: 10.1016/s0003-2697(02)00013-1. Anal Biochem. 2002. PMID: 12137785

3

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.

Colarusso S, Koch U, Gerlach B, Steinkühler C, De Francesco R, Altamura S, Matassa VG, Narjes F. Colarusso S, et al. Among authors: altamura s. J Med Chem. 2003 Jan 30;46(3):345-8. doi: 10.1021/jm025594q. J Med Chem. 2003. PMID: 12540231

4

In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor.

Trozzi C, Bartholomew L, Ceccacci A, Biasiol G, Pacini L, Altamura S, Narjes F, Muraglia E, Paonessa G, Koch U, De Francesco R, Steinkuhler C, Migliaccio G. Trozzi C, et al. Among authors: altamura s. J Virol. 2003 Mar;77(6):3669-79. doi: 10.1128/jvi.77.6.3669-3679.2003. J Virol. 2003. PMID: 12610142 Free PMC article.

5

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

Migliaccio G, Tomassini JE, Carroll SS, Tomei L, Altamura S, Bhat B, Bartholomew L, Bosserman MR, Ceccacci A, Colwell LF, Cortese R, De Francesco R, Eldrup AB, Getty KL, Hou XS, LaFemina RL, Ludmerer SW, MacCoss M, McMasters DR, Stahlhut MW, Olsen DB, Hazuda DJ, Flores OA. Migliaccio G, et al. Among authors: altamura s. J Biol Chem. 2003 Dec 5;278(49):49164-70. doi: 10.1074/jbc.M305041200. Epub 2003 Sep 8. J Biol Chem. 2003. PMID: 12966103 Free article.

6

Mechanism of action and antiviral activity of benzimidazole-based allosteric inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Tomei L, Altamura S, Bartholomew L, Biroccio A, Ceccacci A, Pacini L, Narjes F, Gennari N, Bisbocci M, Incitti I, Orsatti L, Harper S, Stansfield I, Rowley M, De Francesco R, Migliaccio G. Tomei L, et al. Among authors: altamura s. J Virol. 2003 Dec;77(24):13225-31. doi: 10.1128/jvi.77.24.13225-13231.2003. J Virol. 2003. PMID: 14645579 Free PMC article.

7

Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.

Tomei L, Altamura S, Bartholomew L, Bisbocci M, Bailey C, Bosserman M, Cellucci A, Forte E, Incitti I, Orsatti L, Koch U, De Francesco R, Olsen DB, Carroll SS, Migliaccio G. Tomei L, et al. Among authors: altamura s. J Virol. 2004 Jan;78(2):938-46. doi: 10.1128/jvi.78.2.938-946.2004. J Virol. 2004. PMID: 14694125 Free PMC article.

8

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. Among authors: altamura s. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

9

The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase.

Pace P, Nizi E, Pacini B, Pesci S, Matassa V, De Francesco R, Altamura S, Summa V. Pace P, et al. Among authors: altamura s. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3257-61. doi: 10.1016/j.bmcl.2004.03.087. Bioorg Med Chem Lett. 2004. PMID: 15149686

10

HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.

Summa V, Petrocchi A, Matassa VG, Taliani M, Laufer R, De Francesco R, Altamura S, Pace P. Summa V, et al. Among authors: altamura s. J Med Chem. 2004 Oct 21;47(22):5336-9. doi: 10.1021/jm0494669. J Med Chem. 2004. PMID: 15481971

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