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Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection.
Heim CE, Bosch ME, Yamada KJ, Aldrich AL, Chaudhari SS, Klinkebiel D, Gries CM, Alqarzaee AA, Li Y, Thomas VC, Seto E, Karpf AR, Kielian T. Heim CE, et al. Among authors: alqarzaee aa. Nat Microbiol. 2020 Oct;5(10):1271-1284. doi: 10.1038/s41564-020-0756-3. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661313 Free PMC article.
The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant Staphylococcus aureus.
Nielsen TK, Petersen IB, Xu L, Barbuti MD, Mebus V, Justh A, Alqarzaee AA, Jacques N, Oury C, Thomas V, Kjos M, Henriksen C, Frees D. Nielsen TK, et al. Among authors: alqarzaee aa. Antimicrob Agents Chemother. 2024 May 1:e0033524. doi: 10.1128/aac.00335-24. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 38690894