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Machine learning-aided engineering of hydrolases for PET depolymerization.
Lu H, Diaz DJ, Czarnecki NJ, Zhu C, Kim W, Shroff R, Acosta DJ, Alexander BR, Cole HO, Zhang Y, Lynd NA, Ellington AD, Alper HS. Lu H, et al. Among authors: alper hs. Nature. 2022 Apr;604(7907):662-667. doi: 10.1038/s41586-022-04599-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35478237
Rewiring Yarrowia lipolytica toward triacetic acid lactone for materials generation.
Markham KA, Palmer CM, Chwatko M, Wagner JM, Murray C, Vazquez S, Swaminathan A, Chakravarty I, Lynd NA, Alper HS. Markham KA, et al. Among authors: alper hs. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2096-2101. doi: 10.1073/pnas.1721203115. Epub 2018 Feb 12. Proc Natl Acad Sci U S A. 2018. PMID: 29440400 Free PMC article.
Evolving a Generalist Biosensor for Bicyclic Monoterpenes.
d'Oelsnitz S, Nguyen V, Alper HS, Ellington AD. d'Oelsnitz S, et al. Among authors: alper hs. ACS Synth Biol. 2022 Jan 21;11(1):265-272. doi: 10.1021/acssynbio.1c00402. Epub 2022 Jan 5. ACS Synth Biol. 2022. PMID: 34985281
Using fungible biosensors to evolve improved alkaloid biosyntheses.
d'Oelsnitz S, Kim W, Burkholder NT, Javanmardi K, Thyer R, Zhang Y, Alper HS, Ellington AD. d'Oelsnitz S, et al. Among authors: alper hs. Nat Chem Biol. 2022 Sep;18(9):981-989. doi: 10.1038/s41589-022-01072-w. Epub 2022 Jul 7. Nat Chem Biol. 2022. PMID: 35799063
Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme.
d'Oelsnitz S, Diaz DJ, Kim W, Acosta DJ, Dangerfield TL, Schechter MW, Minus MB, Howard JR, Do H, Loy JM, Alper HS, Zhang YJ, Ellington AD. d'Oelsnitz S, et al. Among authors: alper hs. Nat Commun. 2024 Mar 7;15(1):2084. doi: 10.1038/s41467-024-46356-y. Nat Commun. 2024. PMID: 38453941 Free PMC article.
171 results