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Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation.
Deodhar S, Sillman B, Bade AN, Avedissian SN, Podany AT, McMillan JM, Gautam N, Hanson B, Dyavar Shetty BL, Szlachetka A, Johnston M, Thurman M, Munt DJ, Dash AK, Markovic M, Dahan A, Alnouti Y, Yazdi A, Kevadiya BD, Byrareddy SN, Cohen SM, Edagwa B, Gendelman HE. Deodhar S, et al. Among authors: alnouti y. Nat Commun. 2022 Jun 9;13(1):3226. doi: 10.1038/s41467-022-30902-7. Nat Commun. 2022. PMID: 35680875 Free PMC article.
Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles.
Zhou T, Su H, Dash P, Lin Z, Dyavar Shetty BL, Kocher T, Szlachetka A, Lamberty B, Fox HS, Poluektova L, Gorantla S, McMillan J, Gautam N, Mosley RL, Alnouti Y, Edagwa B, Gendelman HE. Zhou T, et al. Among authors: alnouti y. Biomaterials. 2018 Jan;151:53-65. doi: 10.1016/j.biomaterials.2017.10.023. Epub 2017 Oct 15. Biomaterials. 2018. PMID: 29059541 Free PMC article.
Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques.
McMillan J, Szlachetka A, Slack L, Sillman B, Lamberty B, Morsey B, Callen S, Gautam N, Alnouti Y, Edagwa B, Gendelman HE, Fox HS. McMillan J, et al. Among authors: alnouti y. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01316-17. doi: 10.1128/AAC.01316-17. Print 2018 Jan. Antimicrob Agents Chemother. 2017. PMID: 29061742 Free PMC article.
Creation of a long-acting nanoformulated dolutegravir.
Sillman B, Bade AN, Dash PK, Bhargavan B, Kocher T, Mathews S, Su H, Kanmogne GD, Poluektova LY, Gorantla S, McMillan J, Gautam N, Alnouti Y, Edagwa B, Gendelman HE. Sillman B, et al. Among authors: alnouti y. Nat Commun. 2018 Feb 6;9(1):443. doi: 10.1038/s41467-018-02885-x. Nat Commun. 2018. PMID: 29402886 Free PMC article.
ProTide generated long-acting abacavir nanoformulations.
Lin Z , Gautam N , Alnouti Y , McMillan J , Bade AN , Gendelman HE , Edagwa B . Lin Z , et al. Among authors: alnouti y. Chem Commun (Camb). 2018 Jul 24;54(60):8371-8374. doi: 10.1039/c8cc04708a. Chem Commun (Camb). 2018. PMID: 29995046 Free PMC article.
Creation of a long-acting rilpivirine prodrug nanoformulation.
Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Hilaire JR, et al. Among authors: alnouti y. J Control Release. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. Epub 2019 Sep 3. J Control Release. 2019. PMID: 31491432 Free PMC article.
Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation.
Ibrahim IM, Bade AN, Lin Z, Soni D, Wojtkiewicz M, Dyavar Shetty BL, Gautam N, McMillan JM, Alnouti Y, Edagwa BJ, Gendelman HE. Ibrahim IM, et al. Among authors: alnouti y. Int J Nanomedicine. 2019 Aug 7;14:6231-6247. doi: 10.2147/IJN.S215447. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31496683 Free PMC article.
A long acting nanoformulated lamivudine ProTide.
Smith N, Bade AN, Soni D, Gautam N, Alnouti Y, Herskovitz J, Ibrahim IM, Wojtkiewicz MS, Dyavar Shetty BL, McMillan J, Gendelman HE, Edagwa B. Smith N, et al. Among authors: alnouti y. Biomaterials. 2019 Dec;223:119476. doi: 10.1016/j.biomaterials.2019.119476. Epub 2019 Sep 5. Biomaterials. 2019. PMID: 31525692 Free PMC article.
A year-long extended release nanoformulated cabotegravir prodrug.
Kulkarni TA, Bade AN, Sillman B, Shetty BLD, Wojtkiewicz MS, Gautam N, Hilaire JR, Sravanam S, Szlachetka A, Lamberty BG, Morsey BM, Fox HS, Alnouti Y, McMillan JM, Mosley RL, Meza J, Domanico PL, Yue TY, Moore G, Edagwa BJ, Gendelman HE. Kulkarni TA, et al. Among authors: alnouti y. Nat Mater. 2020 Aug;19(8):910-920. doi: 10.1038/s41563-020-0674-z. Epub 2020 Apr 27. Nat Mater. 2020. PMID: 32341511 Free PMC article.
93 results