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Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi.
Wood JM, Satam NS, Almeida RG, Cristani VS, de Lima DP, Dantas-Pereira L, Salomão K, Menna-Barreto RFS, Namboothiri INN, Bower JF, da Silva Júnior EN. Wood JM, et al. Among authors: almeida rg. Bioorg Med Chem. 2020 Aug 1;28(15):115565. doi: 10.1016/j.bmc.2020.115565. Epub 2020 May 30. Bioorg Med Chem. 2020. PMID: 32631558
Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications.
Almeida RG, Valença WO, Rosa LG, de Simone CA, de Castro SL, Barbosa JMC, Pinheiro DP, Paier CRK, de Carvalho GGC, Pessoa C, Goulart MOF, Kharma A, da Silva Júnior EN. Almeida RG, et al. RSC Med Chem. 2020 Jul 13;11(10):1145-1160. doi: 10.1039/d0md00072h. eCollection 2020 Oct 1. RSC Med Chem. 2020. PMID: 33479619 Free PMC article.
It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity.
Lima DJB, Almeida RG, Jardim GAM, Barbosa BPA, Santos ACC, Valença WO, Scheide MR, Gatto CC, de Carvalho GGC, Costa PMS, Pessoa C, Pereira CLM, Jacob C, Braga AL, da Silva Júnior EN. Lima DJB, et al. Among authors: almeida rg. RSC Med Chem. 2021 Aug 12;12(10):1709-1721. doi: 10.1039/d1md00168j. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778772 Free PMC article.
Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2.
Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. Santos LH, et al. Among authors: almeida rg. J Chem Inf Model. 2022 Dec 26;62(24):6553-6573. doi: 10.1021/acs.jcim.2c00693. Epub 2022 Aug 12. J Chem Inf Model. 2022. PMID: 35960688
Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells.
Baiju TV, Almeida RG, Sivanandan ST, de Simone CA, Brito LM, Cavalcanti BC, Pessoa C, Namboothiri INN, da Silva Júnior EN. Baiju TV, et al. Among authors: almeida rg. Eur J Med Chem. 2018 May 10;151:686-704. doi: 10.1016/j.ejmech.2018.03.079. Epub 2018 Apr 5. Eur J Med Chem. 2018. PMID: 29660689
102 results