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Iodination of salicylic acid improves its binding to transthyretin.
Gales L, Almeida MR, Arsequell G, Valencia G, Saraiva MJ, Damas AM. Gales L, et al. Among authors: almeida mr. Biochim Biophys Acta. 2008 Mar;1784(3):512-7. doi: 10.1016/j.bbapap.2007.11.014. Epub 2007 Dec 3. Biochim Biophys Acta. 2008. PMID: 18155178
Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
González A, Quirante J, Nieto J, Almeida MR, Saraiva MJ, Planas A, Arsequell G, Valencia G. González A, et al. Among authors: almeida mr. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5270-3. doi: 10.1016/j.bmcl.2009.03.004. Epub 2009 Mar 6. Bioorg Med Chem Lett. 2009. PMID: 19651509
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.
Sant'Anna R, Gallego P, Robinson LZ, Pereira-Henriques A, Ferreira N, Pinheiro F, Esperante S, Pallares I, Huertas O, Almeida MR, Reixach N, Insa R, Velazquez-Campoy A, Reverter D, Reig N, Ventura S. Sant'Anna R, et al. Among authors: almeida mr. Nat Commun. 2016 Feb 23;7:10787. doi: 10.1038/ncomms10787. Nat Commun. 2016. PMID: 26902880 Free PMC article.
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
Pinheiro F, Pallarès I, Peccati F, Sánchez-Morales A, Varejão N, Bezerra F, Ortega-Alarcon D, Gonzalez D, Osorio M, Navarro S, Velázquez-Campoy A, Almeida MR, Reverter D, Busqué F, Alibés R, Sodupe M, Ventura S. Pinheiro F, et al. Among authors: almeida mr. J Med Chem. 2022 Nov 10;65(21):14673-14691. doi: 10.1021/acs.jmedchem.2c01195. Epub 2022 Oct 28. J Med Chem. 2022. PMID: 36306808 Free PMC article.
377 results