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Page 1
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
Petrocchi A, Grillo A, Ferrante L, Randazzo P, Prandi A, De Matteo M, Iaccarino C, Bisbocci M, Cellucci A, Alli C, Nibbio M, Pucci V, Amaudrut J, Montalbetti C, Toniatti C, Di Fabio R. Petrocchi A, et al. Among authors: alli c. ACS Med Chem Lett. 2023 Apr 17;14(5):645-651. doi: 10.1021/acsmedchemlett.3c00059. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197453 Free PMC article.
Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
Torrente E, Fodale V, Ciammaichella A, Ferrigno F, Ontoria JM, Ponzi S, Rossetti I, Sferrazza A, Amaudrut J, Missineo A, Esposito S, Palombo S, Nibbio M, Cerretani M, Bisbocci M, Cellucci A, di Marco A, Alli C, Pucci V, Toniatti C, Petrocchi A. Torrente E, et al. Among authors: alli c. ACS Med Chem Lett. 2023 Jan 10;14(2):156-162. doi: 10.1021/acsmedchemlett.2c00454. eCollection 2023 Feb 9. ACS Med Chem Lett. 2023. PMID: 36793438 Free PMC article.
Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes.
Paonessa G, Siciliano G, Graziani R, Lalli C, Cecchetti O, Alli C, La Valle R, Petrocchi A, Sferrazza A, Bisbocci M, Falchi M, Toniatti C, Bresciani A, Alano P. Paonessa G, et al. Among authors: alli c. Commun Biol. 2022 Jun 6;5(1):547. doi: 10.1038/s42003-022-03510-w. Commun Biol. 2022. PMID: 35668202 Free PMC article.
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Among authors: alli c. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467 Free PMC article.
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.
Turcano L, Battista T, De Haro ET, Missineo A, Alli C, Paonessa G, Colotti G, Harper S, Fiorillo A, Ilari A, Bresciani A. Turcano L, et al. Among authors: alli c. PLoS Negl Trop Dis. 2020 May 21;14(5):e0008339. doi: 10.1371/journal.pntd.0008339. eCollection 2020 May. PLoS Negl Trop Dis. 2020. PMID: 32437349 Free PMC article.
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Bhat K, et al. Among authors: alli c. Proc Natl Acad Sci U S A. 2020 May 19;117(20):11085-11096. doi: 10.1073/pnas.1920154117. Epub 2020 May 1. Proc Natl Acad Sci U S A. 2020. PMID: 32358191 Free PMC article.
PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E. Zhang L, et al. Among authors: alli c. Breast Cancer Res Treat. 2019 Nov;178(1):75-86. doi: 10.1007/s10549-019-05376-9. Epub 2019 Aug 1. Breast Cancer Res Treat. 2019. PMID: 31372790 Free PMC article.
1-(4-nitrobenzenesulfonyl)-4-penylpiperazine increases the number of Peyer's patch-associated regenerating crypts in the small intestines after radiation injury.
Bhat K, Duhachek-Muggy S, Ramanathan R, Saki M, Alli C, Medina P, Damoiseaux R, Whitelegge J, McBride WH, Schaue D, Vlashi E, Pajonk F. Bhat K, et al. Among authors: alli c. Radiother Oncol. 2019 Mar;132:8-15. doi: 10.1016/j.radonc.2018.11.011. Epub 2018 Dec 20. Radiother Oncol. 2019. PMID: 30825974 Free PMC article.
70 results