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Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality.
Cooper CE , Silkstone GGA , Simons M , Gretton S , Rajagopal BS , Allen-Baume V , Syrett N , Shaik T , Popa G , Sheng X , Bird M , Choi JW , Piano R , Ronda L , Bettati S , Paredi G , Mozzarelli A , Reeder BJ . Cooper CE , et al. Biomater Sci. 2020 Jul 21;8(14):3896-3906. doi: 10.1039/c9bm01773a. Epub 2020 Jun 15. Biomater Sci. 2020. PMID: 32539053
Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers.
Simons M, Gretton S, Silkstone GGA, Rajagopal BS, Allen-Baume V, Syrett N, Shaik T, Leiva-Eriksson N, Ronda L, Mozzarelli A, Strader MB, Alayash AI, Reeder BJ, Cooper CE. Simons M, et al. Biosci Rep. 2018 Jul 2;38(4):BSR20180370. doi: 10.1042/BSR20180370. Print 2018 Aug 31. Biosci Rep. 2018. PMID: 29802155 Free PMC article.
Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes.
Morgan CP, Skippen A, Segui B, Ball A, Allen-Baume V, Larijani B, Murray-Rust J, McDonald N, Sapkota G, Morrice N, Cockcroft S. Morgan CP, et al. J Biol Chem. 2004 Nov 5;279(45):47159-71. doi: 10.1074/jbc.M405827200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322105 Free article.