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Plasticity of human CD4 T cell subsets.
Geginat J, Paroni M, Maglie S, Alfen JS, Kastirr I, Gruarin P, De Simone M, Pagani M, Abrignani S. Geginat J, et al. Among authors: alfen js. Front Immunol. 2014 Dec 16;5:630. doi: 10.3389/fimmu.2014.00630. eCollection 2014. Front Immunol. 2014. PMID: 25566245 Free PMC article. Review.
IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells.
Kastirr I, Maglie S, Paroni M, Alfen JS, Nizzoli G, Sugliano E, Crosti MC, Moro M, Steckel B, Steinfelder S, Stölzel K, Romagnani C, Botti F, Caprioli F, Pagani M, Abrignani S, Geginat J. Kastirr I, et al. Among authors: alfen js. J Immunol. 2014 Oct 1;193(7):3322-31. doi: 10.4049/jimmunol.1400775. Epub 2014 Aug 29. J Immunol. 2014. PMID: 25172491 Clinical Trial.
IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus.
Facciotti F, Gagliani N, Häringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stölzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, Pignataro L, Annoni A, Russo F, Pagani M, Abrignani S, Meroni P, Flavell R, Geginat J. Facciotti F, et al. Among authors: alfen js. J Allergy Clin Immunol. 2016 Jan;137(1):318-321.e5. doi: 10.1016/j.jaci.2015.06.044. Epub 2015 Aug 25. J Allergy Clin Immunol. 2016. PMID: 26318071 No abstract available.
Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease.
Alfen JS, Larghi P, Facciotti F, Gagliani N, Bosotti R, Paroni M, Maglie S, Gruarin P, Vasco CM, Ranzani V, Frusteri C, Iseppon A, Moro M, Crosti MC, Gatti S, Pagani M, Caprioli F, Abrignani S, Flavell RA, Geginat J. Alfen JS, et al. J Allergy Clin Immunol. 2018 Nov;142(5):1537-1547.e8. doi: 10.1016/j.jaci.2017.12.984. Epub 2018 Jan 31. J Allergy Clin Immunol. 2018. PMID: 29369775 Free article.