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Page 1
Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons.
Fernandez A, Corvalan K, Santis O, Mendez-Ruette M, Caviedes A, Pizarro M, Gomez MT, Batiz LF, Landgraf P, Kahne T, Rojas-Fernandez A, Wyneken U. Fernandez A, et al. Among authors: rojas fernandez a. Brain Res. 2024 Jan 15;1823:148679. doi: 10.1016/j.brainres.2023.148679. Epub 2023 Nov 14. Brain Res. 2024. PMID: 37972846
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ. Aguado J, et al. Among authors: rojas fernandez a. Nat Aging. 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Nat Aging. 2023. PMID: 37957361 Free PMC article.
Indomethacin Induces Spermidine/Spermine-N1-Acetyltransferase-1 via the Nucleolin-CDK1 Axis and Synergizes with the Polyamine Oxidase Inhibitor Methoctramine in Lung Cancer Cells.
Buelvas N, Ugarte-Vio I, Asencio-Leal L, Muñoz-Uribe M, Martin-Martin A, Rojas-Fernández A, Jara JA, Tapia JC, Arias ME, López-Muñoz RA. Buelvas N, et al. Among authors: rojas fernandez a. Biomolecules. 2023 Sep 12;13(9):1383. doi: 10.3390/biom13091383. Biomolecules. 2023. PMID: 37759783 Free PMC article.
A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants.
Modhiran N, Lauer SM, Amarilla AA, Hewins P, Lopes van den Broek SI, Low YS, Thakur N, Liang B, Nieto GV, Jung J, Paramitha D, Isaacs A, Sng JDJ, Song D, Jørgensen JT, Cheuquemilla Y, Bürger J, Andersen IV, Himelreichs J, Jara R, MacLoughlin R, Miranda-Chacon Z, Chana-Cuevas P, Kramer V, Spahn C, Mielke T, Khromykh AA, Munro T, Jones ML, Young PR, Chappell K, Bailey D, Kjaer A, Herth MM, Jurado KA, Schwefel D, Rojas-Fernandez A, Watterson D. Modhiran N, et al. Among authors: rojas fernandez a. iScience. 2023 Jun 9;26(7):107085. doi: 10.1016/j.isci.2023.107085. eCollection 2023 Jul 21. iScience. 2023. PMID: 37361875 Free PMC article.
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. Albornoz EA, et al. Among authors: rojas fernandez a. Mol Psychiatry. 2023 Jul;28(7):2878-2893. doi: 10.1038/s41380-022-01831-0. Epub 2022 Nov 1. Mol Psychiatry. 2023. PMID: 36316366 Free PMC article.
Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival.
Vargas G, Cortés O, Arias-Muñoz E, Hernández S, Cerda-Troncoso C, Hernández L, González AE, Tatham MH, Bustamante HA, Retamal C, Cancino J, Varas-Godoy M, Hay RT, Rojas-Fernández A, Cavieres VA, Burgos PV. Vargas G, et al. Among authors: rojas fernandez a. Front Cell Dev Biol. 2022 Mar 2;10:743287. doi: 10.3389/fcell.2022.743287. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35309917 Free PMC article.
Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and Amygdala.
Del Rey NL, Balzano T, Martin-Rodriguez L, Salinas-Rebolledo C, Trigo-Damas I, Rojas-Fernandez A, Alvarez-Erviti L, Blesa J. Del Rey NL, et al. Among authors: rojas fernandez a. Front Aging Neurosci. 2021 Oct 21;13:698979. doi: 10.3389/fnagi.2021.698979. eCollection 2021. Front Aging Neurosci. 2021. PMID: 34744683 Free PMC article.
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody.
Valenzuela Nieto G, Jara R, Watterson D, Modhiran N, Amarilla AA, Himelreichs J, Khromykh AA, Salinas-Rebolledo C, Pinto T, Cheuquemilla Y, Margolles Y, López González Del Rey N, Miranda-Chacon Z, Cuevas A, Berking A, Deride C, González-Moraga S, Mancilla H, Maturana D, Langer A, Toledo JP, Müller A, Uberti B, Krall P, Ehrenfeld P, Blesa J, Chana-Cuevas P, Rehren G, Schwefel D, Fernandez LÁ, Rojas-Fernandez A. Valenzuela Nieto G, et al. Among authors: rojas fernandez a. Sci Rep. 2021 Feb 8;11(1):3318. doi: 10.1038/s41598-021-82833-w. Sci Rep. 2021. PMID: 33558635 Free PMC article.
22 results