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Showing results for aldara ha
Search for Aldare HA instead (1 results)
Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.
Palefsky JM, Lee JY, Jay N, Goldstone SE, Darragh TM, Dunlevy HA, Rosa-Cunha I, Arons A, Pugliese JC, Vena D, Sparano JA, Wilkin TJ, Bucher G, Stier EA, Tirado Gomez M, Flowers L, Barroso LF, Mitsuyasu RT, Lensing SY, Logan J, Aboulafia DM, Schouten JT, de la Ossa J, Levine R, Korman JD, Hagensee M, Atkinson TM, Einstein MH, Cracchiolo BM, Wiley D, Ellsworth GB, Brickman C, Berry-Lawhorn JM; ANCHOR Investigators Group. Palefsky JM, et al. N Engl J Med. 2022 Jun 16;386(24):2273-2282. doi: 10.1056/NEJMoa2201048. N Engl J Med. 2022. PMID: 35704479 Free PMC article. Clinical Trial.
Treatment included office-based ablative procedures, ablation or excision under anesthesia, or the administration of topical fluorouracil or imiquimod. The primary outcome was progression to anal cancer in a time-to-event analysis. ...
Treatment included office-based ablative procedures, ablation or excision under anesthesia, or the administration of topical fluorouracil or …
Hyaluronic Acid-Based Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of Psoriasis.
Du H, Liu P, Zhu J, Lan J, Li Y, Zhang L, Zhu J, Tao J. Du H, et al. ACS Appl Mater Interfaces. 2019 Nov 20;11(46):43588-43598. doi: 10.1021/acsami.9b15668. Epub 2019 Nov 8. ACS Appl Mater Interfaces. 2019. PMID: 31651148
To address these limitations, we developed a dissolving microneedle (MN) patch made of hyaluronic acid (HA) with excellent water solubility, biocompatibility, biodegradability, and mechanical properties. ...Meanwhile, fast dissolution of HA endowed the MNs with oper …
To address these limitations, we developed a dissolving microneedle (MN) patch made of hyaluronic acid (HA) with excellent water solu …
Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation.
Ikeda K, Morizane S, Akagi T, Hiramatsu-Asano S, Tachibana K, Yahagi A, Iseki M, Kaneto H, Wada J, Ishihara K, Morita Y, Mukai T. Ikeda K, et al. Int J Mol Sci. 2022 Apr 13;23(8):4312. doi: 10.3390/ijms23084312. Int J Mol Sci. 2022. PMID: 35457132 Free PMC article.
To investigate the mechanisms by which obesity and dyslipidemia exacerbate psoriasis using murine models and neonatal human epidermal keratinocytes (NHEKs), we used wild-type and Apoe-deficient dyslipidemic mice, and administered a high-fat diet for 10 weeks to induce obesity. …
To investigate the mechanisms by which obesity and dyslipidemia exacerbate psoriasis using murine models and neonatal human epidermal kerati …
CD44 targeted indirubin nanocrystal-loaded hyaluronic acid hydrogel for the treatment of psoriasis.
Li L, Liu C, Fu J, Wang Y, Yang D, Peng B, Liu X, Han X, Meng Y, Feng F, Hu X, Qi C, Wang Y, Zheng Y, Li P. Li L, et al. Int J Biol Macromol. 2023 Jul 15;243:125239. doi: 10.1016/j.ijbiomac.2023.125239. Epub 2023 Jun 8. Int J Biol Macromol. 2023. PMID: 37295696
Indirubin nanocrystals (NCs) were prepared through wet media milling and were then mixed with HA to create indirubin NC/HA gels. A mouse model of imiquimod (IMQ)-induced psoriasis and M5-induced keratinocyte proliferation were established. Then, the efficacy …
Indirubin nanocrystals (NCs) were prepared through wet media milling and were then mixed with HA to create indirubin NC/HA gel …
Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer.
Singh B, Maharjan S, Pan DC, Zhao Z, Gao Y, Zhang YS, Mitragotri S. Singh B, et al. Biomaterials. 2022 Jan;280:121302. doi: 10.1016/j.biomaterials.2021.121302. Epub 2021 Nov 30. Biomaterials. 2022. PMID: 34894584
While gemcitabine monotherapy remains a choice of standard treatment for advanced breast cancer, the approach has not prolonged the median survival time of metastatic breast cancer patients. Here, we report a hyaluronic acid (HA)-based drug combination of gemcitabine (GEM) …
While gemcitabine monotherapy remains a choice of standard treatment for advanced breast cancer, the approach has not prolonged the median s …
Bidirectional anisotropic palladium nanozymes reprogram macrophages to enhance collaborative chemodynamic therapy of colorectal cancer.
Chen X, Jia Z, Wen Y, Huang Y, Yuan X, Chen Y, Liu Y, Liu J. Chen X, et al. Acta Biomater. 2022 Oct 1;151:537-548. doi: 10.1016/j.actbio.2022.08.020. Epub 2022 Aug 15. Acta Biomater. 2022. PMID: 35981687
In these nanoclusters, the Pd-HA part was obtained by modifying hyaluronic acid (HA) on the surface of ultra-small Pd nanozymes that could target CT26 cells. ...STATEMENT OF SIGNIFICANCE: The bidirectional anisotropic Pd nanoclusters (Pd-HA+Pd-M@R NPs) that c …
In these nanoclusters, the Pd-HA part was obtained by modifying hyaluronic acid (HA) on the surface of ultra-small Pd nanozyme …
IL-20-Receptor Signaling Delimits IL-17 Production in Psoriatic Inflammation.
Ha HL, Wang H, Claudio E, Tang W, Siebenlist U. Ha HL, et al. J Invest Dermatol. 2020 Jan;140(1):143-151.e3. doi: 10.1016/j.jid.2019.06.127. Epub 2019 Jun 26. J Invest Dermatol. 2020. PMID: 31252033 Free PMC article.
In this study, we demonstrate that signaling via IL-20 receptors, including in response to IL-19, delimited aspects of imiquimod-induced psoriatic inflammation. IL-20 receptor signaling suppressed the dermal production of the CCL2 chemokine and thereby reduced CCL-2-driven …
In this study, we demonstrate that signaling via IL-20 receptors, including in response to IL-19, delimited aspects of imiquimod-indu …
Efficient local delivery of FK506 using blocking patches in psoriasis.
Zhao Z, Wang H, Yao L, Zhang X, Yu Q, Gu J, Shi Y. Zhao Z, et al. J Colloid Interface Sci. 2023 Jan 15;630(Pt A):676-687. doi: 10.1016/j.jcis.2022.09.146. Epub 2022 Oct 5. J Colloid Interface Sci. 2023. PMID: 36274404
In this study, which was inspired by local block injection used in the clinical treatment for keloid, a hyaluronic acid (HA) based system to transport FK506 into the skin to treat psoriasis, named blocking patch (BP) was developed. ...Further animal studies revealed that F …
In this study, which was inspired by local block injection used in the clinical treatment for keloid, a hyaluronic acid (HA) based sy …
NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses.
Zhang L, Zhang J, Xu L, Zhuang Z, Liu J, Liu S, Wu Y, Gong A, Zhang M, Du F. Zhang L, et al. J Nanobiotechnology. 2021 May 17;19(1):142. doi: 10.1186/s12951-021-00880-x. J Nanobiotechnology. 2021. PMID: 34001148 Free PMC article.
RESULTS: HA-PDA@IQ NPs with high photothermal conversion efficiency (41.2%) and T(1)-relaxation efficiency were using HA as stabilizer by the one-pot oxidative polymerization. Then, HA-PDA@IQ loaded DOX via pi-pi stacking and mixed with thermal-sensitive hydr …
RESULTS: HA-PDA@IQ NPs with high photothermal conversion efficiency (41.2%) and T(1)-relaxation efficiency were using HA as st …
32 results