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Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Rué L, Bañez-Coronel M, Creus-Muncunill J, Giralt A, Alcalá-Vida R, Mentxaka G, Kagerbauer B, Zomeño-Abellán MT, Aranda Z, Venturi V, Pérez-Navarro E, Estivill X, Martí E. Rué L, et al. Among authors: alcala vida r. J Clin Invest. 2016 Nov 1;126(11):4319-4330. doi: 10.1172/JCI83185. Epub 2016 Oct 10. J Clin Invest. 2016. PMID: 27721240 Free PMC article.
Chelerythrine promotes Ca2+-dependent calpain activation in neuronal cells in a PKC-independent manner.
Saavedra A, Fernández-García S, Cases S, Puigdellívol M, Alcalá-Vida R, Martín-Flores N, Alberch J, Ginés S, Malagelada C, Pérez-Navarro E. Saavedra A, et al. Among authors: alcala vida r. Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):922-935. doi: 10.1016/j.bbagen.2017.01.021. Epub 2017 Jan 24. Biochim Biophys Acta Gen Subj. 2017. PMID: 28130160
Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease.
Alcalá-Vida R, Garcia-Forn M, Castany-Pladevall C, Creus-Muncunill J, Ito Y, Blanco E, Golbano A, Crespí-Vázquez K, Parry A, Slater G, Samarajiwa S, Peiró S, Di Croce L, Narita M, Pérez-Navarro E. Alcalá-Vida R, et al. EMBO Mol Med. 2021 Feb 5;13(2):e12105. doi: 10.15252/emmm.202012105. Epub 2020 Dec 28. EMBO Mol Med. 2021. PMID: 33369245 Free PMC article.
Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration.
Creus-Muncunill J, Rué L, Alcalá-Vida R, Badillos-Rodríguez R, Romaní-Aumedes J, Marco S, Alberch J, Perez-Otaño I, Malagelada C, Pérez-Navarro E. Creus-Muncunill J, et al. Among authors: alcala vida r. Mol Neurobiol. 2018 Oct;55(10):7728-7742. doi: 10.1007/s12035-018-0956-5. Epub 2018 Feb 19. Mol Neurobiol. 2018. PMID: 29460266 Free article.
12 results