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Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.
Azad T, Rezaei R, Singaravelu R, Pelin A, Boulton S, Petryk J, Onsu KA, Martin NT, Hoskin V, Ghahremani M, Marotel M, Marius R, He X, Crupi MJF, Hoang HD, Nik-Akhtar A, Ahmadi M, Zamani NK, Golshani A, Alain T, Greer P, Ardolino M, Dickinson BC, Tai LH, Ilkow CS, Bell JC. Azad T, et al. Among authors: alain t. Nat Commun. 2023 May 26;14(1):3035. doi: 10.1038/s41467-023-38651-x. Nat Commun. 2023. PMID: 37236967 Free PMC article.
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N. Morita M, et al. Among authors: alain t. Mol Cell Biol. 2012 Sep;32(17):3585-93. doi: 10.1128/MCB.00455-12. Epub 2012 Jul 2. Mol Cell Biol. 2012. PMID: 22751931 Free PMC article.
Distinct perturbation of the translatome by the antidiabetic drug metformin.
Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N. Larsson O, et al. Among authors: alain t. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8977-82. doi: 10.1073/pnas.1201689109. Epub 2012 May 18. Proc Natl Acad Sci U S A. 2012. PMID: 22611195 Free PMC article.
Reovirus therapy of lymphoid malignancies.
Alain T, Hirasawa K, Pon KJ, Nishikawa SG, Urbanski SJ, Auer Y, Luider J, Martin A, Johnston RN, Janowska-Wieczorek A, Lee PW, Kossakowska AE. Alain T, et al. Blood. 2002 Dec 1;100(12):4146-53. doi: 10.1182/blood-2002-02-0503. Epub 2002 Jul 25. Blood. 2002. PMID: 12393565 Free article.
Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.
Fonseca BD, Alain T, Finestone LK, Huang BP, Rolfe M, Jiang T, Yao Z, Hernandez G, Bennett CF, Proud CG. Fonseca BD, et al. Among authors: alain t. J Biol Chem. 2011 Aug 5;286(31):27111-22. doi: 10.1074/jbc.M111.260794. Epub 2011 Jun 9. J Biol Chem. 2011. PMID: 21659537 Free PMC article.
Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex.
Gandin V, Gutierrez GJ, Brill LM, Varsano T, Feng Y, Aza-Blanc P, Au Q, McLaughlan S, Ferreira TA, Alain T, Sonenberg N, Topisirovic I, Ronai ZA. Gandin V, et al. Among authors: alain t. Mol Cell Biol. 2013 Jul;33(13):2510-26. doi: 10.1128/MCB.01362-12. Epub 2013 Apr 22. Mol Cell Biol. 2013. PMID: 23608534 Free PMC article.
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.
Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. Alain T, et al. Cancer Res. 2012 Dec 15;72(24):6468-76. doi: 10.1158/0008-5472.CAN-12-2395. Epub 2012 Oct 24. Cancer Res. 2012. PMID: 23100465
111 results