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Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicing.
Borrajo J, Javanmardi K, Griffin J, St Martin SJ, Yao D, Hill K, Blainey PC, Al-Shayeb B. Borrajo J, et al. Among authors: al shayeb b. bioRxiv [Preprint]. 2023 Aug 18:2023.08.18.553620. doi: 10.1101/2023.08.18.553620. bioRxiv. 2023. PMID: 37645763 Free PMC article. Preprint.
Genome expansion by a CRISPR trimmer-integrase.
Wang JY, Tuck OT, Skopintsev P, Soczek KM, Li G, Al-Shayeb B, Zhou J, Doudna JA. Wang JY, et al. Among authors: al shayeb b. Nature. 2023 Jun;618(7966):855-861. doi: 10.1038/s41586-023-06178-2. Epub 2023 Jun 14. Nature. 2023. PMID: 37316664 Free PMC article.
Genome editing in plants using the compact editor CasΦ.
Li Z, Zhong Z, Wu Z, Pausch P, Al-Shayeb B, Amerasekera J, Doudna JA, Jacobsen SE. Li Z, et al. Among authors: al shayeb b. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2216822120. doi: 10.1073/pnas.2216822120. Epub 2023 Jan 18. Proc Natl Acad Sci U S A. 2023. PMID: 36652483 Free PMC article.
Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors.
Al-Shayeb B, Skopintsev P, Soczek KM, Stahl EC, Li Z, Groover E, Smock D, Eggers AR, Pausch P, Cress BF, Huang CJ, Staskawicz B, Savage DF, Jacobsen SE, Banfield JF, Doudna JA. Al-Shayeb B, et al. Cell. 2022 Nov 23;185(24):4574-4586.e16. doi: 10.1016/j.cell.2022.10.020. Cell. 2022. PMID: 36423580 Free article.
Borgs are giant genetic elements with potential to expand metabolic capacity.
Al-Shayeb B, Schoelmerich MC, West-Roberts J, Valentin-Alvarado LE, Sachdeva R, Mullen S, Crits-Christoph A, Wilkins MJ, Williams KH, Doudna JA, Banfield JF. Al-Shayeb B, et al. Nature. 2022 Oct;610(7933):731-736. doi: 10.1038/s41586-022-05256-1. Epub 2022 Oct 19. Nature. 2022. PMID: 36261517 Free PMC article.
Petabase-scale sequence alignment catalyses viral discovery.
Edgar RC, Taylor B, Lin V, Altman T, Barbera P, Meleshko D, Lohr D, Novakovsky G, Buchfink B, Al-Shayeb B, Banfield JF, de la Peña M, Korobeynikov A, Chikhi R, Babaian A. Edgar RC, et al. Among authors: al shayeb b. Nature. 2022 Feb;602(7895):142-147. doi: 10.1038/s41586-021-04332-2. Epub 2022 Jan 26. Nature. 2022. PMID: 35082445
DNA interference states of the hypercompact CRISPR-CasΦ effector.
Pausch P, Soczek KM, Herbst DA, Tsuchida CA, Al-Shayeb B, Banfield JF, Nogales E, Doudna JA. Pausch P, et al. Among authors: al shayeb b. Nat Struct Mol Biol. 2021 Aug;28(8):652-661. doi: 10.1038/s41594-021-00632-3. Epub 2021 Aug 11. Nat Struct Mol Biol. 2021. PMID: 34381246 Free PMC article.
Tools for interpretation of wastewater SARS-CoV-2 temporal and spatial trends demonstrated with data collected in the San Francisco Bay Area.
Greenwald HD, Kennedy LC, Hinkle A, Whitney ON, Fan VB, Crits-Christoph A, Harris-Lovett S, Flamholz AI, Al-Shayeb B, Liao LD, Beyers M, Brown D, Chakrabarti AR, Dow J, Frost D, Koekemoer M, Lynch C, Sarkar P, White E, Kantor R, Nelson KL. Greenwald HD, et al. Among authors: al shayeb b. Water Res X. 2021 Aug 1;12:100111. doi: 10.1016/j.wroa.2021.100111. Epub 2021 Jul 31. Water Res X. 2021. PMID: 34373850 Free PMC article.
23 results