Al-Majid A - Search Results

1

Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules.

Barakat A, Alshahrani S, Al-Majid AM, Alamary AS, Haukka M, Abu-Serie MM, Dömling A, Domingo LR, Elshaier YAMM. Barakat A, et al. Among authors: al majid am. Front Pharmacol. 2024 Apr 8;15:1358089. doi: 10.3389/fphar.2024.1358089. eCollection 2024. Front Pharmacol. 2024. PMID: 38650632 Free PMC article.

2

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells.

Nafie MS, Al-Majid AM, Ali M, Alayyaf AA, Haukka M, Ashraf S, Ul-Haq Z, El-Faham A, Barakat A. Nafie MS, et al. Among authors: al majid am. Front Chem. 2024 Feb 29;12:1364378. doi: 10.3389/fchem.2024.1364378. eCollection 2024. Front Chem. 2024. PMID: 38487783 Free PMC article.

3

Corrigendum to "Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma" [Bioorg. Chem. 129 (2022) 106124].

Barakat A, Alshahrani S, Al-Majid AM, Alamary AS, Haukka M, Abu-Serie MM, Dömling A, Mazyed EA, Badria FA, El-Senduny FF. Barakat A, et al. Among authors: al majid am. Bioorg Chem. 2024 Feb;143:107012. doi: 10.1016/j.bioorg.2023.107012. Epub 2023 Dec 8. Bioorg Chem. 2024. PMID: 38071087 No abstract available.

4

New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights.

Barakat A, Alshahrani S, Al-Majid AM, Alamary AS, Haukka M, Abu-Serie MM, Domingo LR, Ashraf S, Ul-Haq Z, Nafie MS, Teleb M. Barakat A, et al. Among authors: al majid am. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2281260. doi: 10.1080/14756366.2023.2281260. Epub 2023 Nov 23. J Enzyme Inhib Med Chem. 2023. PMID: 37994663 Free PMC article.

5

Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity.

Alshahrani S, Al-Majid AM, Alamary AS, Ali M, Altowyan MS, Ríos-Gutiérrez M, Yousuf S, Barakat A. Alshahrani S, et al. Among authors: al majid am. Molecules. 2023 Oct 8;28(19):6976. doi: 10.3390/molecules28196976. Molecules. 2023. PMID: 37836817 Free PMC article.

6

A novel alpha-amylase inhibitor-based spirooxindole-pyrrolidine-clubbed thiochromene-pyrzaole pharmacophores: Unveiling the [3+2] cycloaddition reaction by molecular electron density theory.

Islam MS, Al-Majid AM, Haukka M, Parveen Z, Ravaiz N, Wadood A, Rehman AU, Ríos-Gutiérrez M, Domingo LR, Barakat A. Islam MS, et al. Among authors: al majid am. Chem Biol Drug Des. 2023 Nov;102(5):972-995. doi: 10.1111/cbdd.14299. Epub 2023 Aug 10. Chem Biol Drug Des. 2023. PMID: 37563748

7

Synthesis and SARs study of novel spiro-oxindoles as potent antiproliferative agents with CDK-2 inhibitory activities.

Al-Jassas RM, Islam MS, Al-Majid AM, Nafie MS, Haukka M, Rahman AFMM, Alayyaf AMA, Barakat A. Al-Jassas RM, et al. Among authors: al majid am. Arch Pharm (Weinheim). 2023 Aug;356(8):e2300185. doi: 10.1002/ardp.202300185. Epub 2023 May 30. Arch Pharm (Weinheim). 2023. PMID: 37253118

8

Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells.

Islam MS, Al-Majid AM, Sholkamy EN, Barakat A, Viale M, Menichini P, Speciale A, Loiacono F, Azam M, Verma VP, Yousuf S, Teleb M. Islam MS, et al. Among authors: al majid am. Sci Rep. 2023 May 8;13(1):7441. doi: 10.1038/s41598-023-31209-3. Sci Rep. 2023. PMID: 37156796 Free PMC article.

9

Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination Studies.

Barakat A, Mostafa A, Ali M, Al-Majid AM, Domingo LR, Kutkat O, Moatasim Y, Zia K, Ul-Haq Z, Elshaier YAMM. Barakat A, et al. Among authors: al majid am. Int J Mol Sci. 2022 Oct 6;23(19):11861. doi: 10.3390/ijms231911861. Int J Mol Sci. 2022. PMID: 36233160 Free PMC article.

10

Mechanistic Evaluation of the Stability of Arylvinyl-1,2,4-trioxanes under Acidic Conditions for Their Oral Administration as an Antimalarial Drug.

Kumari A, Karnatak M, Singh AS, Hassam M, Rawat V, Islam MS, Al-Majid AM, Singh M, Verma VP. Kumari A, et al. Among authors: al majid am. ACS Omega. 2022 May 17;7(21):17984-17994. doi: 10.1021/acsomega.2c01321. eCollection 2022 May 31. ACS Omega. 2022. PMID: 35664617 Free PMC article.

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