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Molecular docking and dynamic studies of a potential therapeutic target inhibiting glyoxalase system: Metabolic action of the 3, 3 '- [3- (5-chloro-2-hydroxyphenyl) -3-oxopropane-1, 1-diyl] - Bis-4-hydroxycoumarin leads overexpression of the intracellular level of methylglyoxal and induction of a pro-apoptotic phenomenon in a hepatocellular carcinoma model.
Chem Biol Interact. 2021 Aug 25;345:109511. doi: 10.1016/j.cbi.2021.109511. Epub 2021 May 11.
Chem Biol Interact. 2021.
PMID: 33989593
Development of analytical methods GC-MS vs LC-UV for the serum monitoring of an inflammatory glycotoxin (methylglyoxal): A new biomarker of bovine hepatobiliary distomatosis.
Taïbi N, Taïbi A, Ameraoui R, Abou-Mustapha M, Hadjadj M, Boutaiba ZM, Kaced A, Djema S, Al-Balas QA, Al Jabal GA, Aissi M, Harhoura K, Zenia S, Khammar F.
Taïbi N, et al. Among authors: al jabal ga.
Biochimie. 2020 Jan;168:169-184. doi: 10.1016/j.biochi.2019.11.002. Epub 2019 Nov 7.
Biochimie. 2020.
PMID: 31707099
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Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors.
Al-Balas QA, Al-Smadi ML, Hassan MA, Al Jabal GA, Almaaytah AM, Alzoubi KH.
Al-Balas QA, et al. Among authors: al jabal ga.
Molecules. 2019 Sep 4;24(18):3210. doi: 10.3390/molecules24183210.
Molecules. 2019.
PMID: 31487813
Free PMC article.
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Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents.
Al-Sha'er MA, Al-Balas QA, Hassan MA, Al Jabal GA, Almaaytah AM.
Al-Sha'er MA, et al. Among authors: al jabal ga.
Comput Biol Chem. 2019 Jun;80:102-110. doi: 10.1016/j.compbiolchem.2019.03.011. Epub 2019 Mar 25.
Comput Biol Chem. 2019.
PMID: 30947068
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Recent Advances in Glyoxalase-I Inhibition.
Al-Balas QA, Hassan MA, Al-Shar'i NA, Al Jabal GA, Almaaytah AM.
Al-Balas QA, et al. Among authors: al jabal ga.
Mini Rev Med Chem. 2019;19(4):281-291. doi: 10.2174/1389557518666181009141231.
Mini Rev Med Chem. 2019.
PMID: 30306863
Review.
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