Akhlaghi F - Search Results

1

Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457.

Sulima A, Akhlaghi F, Leggio L, Rice KC. Sulima A, et al. Among authors: akhlaghi f. Bioorg Med Chem. 2021 Nov 15;50:116465. doi: 10.1016/j.bmc.2021.116465. Epub 2021 Oct 12. Bioorg Med Chem. 2021. PMID: 34662828 Free PMC article.

2

Development and validation of an UPLC-MS/MS assay for quantitative analysis of the ghrelin receptor inverse agonist PF-5190457 in human or rat plasma and rat brain.

Ghareeb M, Leggio L, El-Kattan A, Akhlaghi F. Ghareeb M, et al. Among authors: akhlaghi f. Anal Bioanal Chem. 2015 Jul;407(19):5603-13. doi: 10.1007/s00216-015-8730-2. Epub 2015 May 7. Anal Bioanal Chem. 2015. PMID: 25943263 Free PMC article.

3

Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks?

Haass-Koffler CL, Akhlaghi F, Swift RM, Leggio L. Haass-Koffler CL, et al. Among authors: akhlaghi f. J Psychopharmacol. 2017 Jul;31(7):812-818. doi: 10.1177/0269881116684338. Epub 2017 Jan 16. J Psychopharmacol. 2017. PMID: 28093021 Free PMC article. Review.

4

Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay.

Lee MR, Scheidweiler KB, Diao XX, Akhlaghi F, Cummins A, Huestis MA, Leggio L, Averbeck BB. Lee MR, et al. Among authors: akhlaghi f. Mol Psychiatry. 2018 Jan;23(1):115-122. doi: 10.1038/mp.2017.27. Epub 2017 Mar 14. Mol Psychiatry. 2018. PMID: 28289281 Free PMC article.

5

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study.

Lee MR, Tapocik JD, Ghareeb M, Schwandt ML, Dias AA, Le AN, Cobbina E, Farinelli LA, Bouhlal S, Farokhnia M, Heilig M, Akhlaghi F, Leggio L. Lee MR, et al. Among authors: akhlaghi f. Mol Psychiatry. 2020 Feb;25(2):461-475. doi: 10.1038/s41380-018-0064-y. Epub 2018 May 4. Mol Psychiatry. 2020. PMID: 29728704 Free PMC article. Clinical Trial.

6

Identifying and Characterizing Subpopulations of Heavy Alcohol Drinkers Via a Sucrose Preference Test: A Sweet Road to a Better Phenotypic Characterization?

Bouhlal S, Farokhnia M, Lee MR, Akhlaghi F, Leggio L. Bouhlal S, et al. Among authors: akhlaghi f. Alcohol Alcohol. 2018 Sep 1;53(5):560-569. doi: 10.1093/alcalc/agy048. Alcohol Alcohol. 2018. PMID: 30016385 Free PMC article.

7

Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?

Farokhnia M, Lee MR, Farinelli LA, Ramchandani VA, Akhlaghi F, Leggio L. Farokhnia M, et al. Among authors: akhlaghi f. Pharmacol Biochem Behav. 2018 Sep;172:39-49. doi: 10.1016/j.pbb.2018.07.004. Epub 2018 Jul 17. Pharmacol Biochem Behav. 2018. PMID: 30030128 Clinical Trial.

8

A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation.

Farokhnia M, Deschaine SL, Sadighi A, Farinelli LA, Lee MR, Akhlaghi F, Leggio L. Farokhnia M, et al. Among authors: akhlaghi f. Mol Psychiatry. 2021 Feb;26(2):545-555. doi: 10.1038/s41380-018-0287-y. Epub 2018 Oct 31. Mol Psychiatry. 2021. PMID: 30382188 Free PMC article. Clinical Trial.

9

Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.

Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F. Adusumalli S, et al. Among authors: akhlaghi f. Drug Metab Dispos. 2019 Aug;47(8):874-882. doi: 10.1124/dmd.119.087015. Epub 2019 Jun 10. Drug Metab Dispos. 2019. PMID: 31182423 Free PMC article. Clinical Trial.

10

Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers.

Lee MR, Farokhnia M, Cobbina E, Saravanakumar A, Li X, Battista JT, Farinelli LA, Akhlaghi F, Leggio L. Lee MR, et al. Among authors: akhlaghi f. Neuropharmacology. 2020 Jun 15;170:107788. doi: 10.1016/j.neuropharm.2019.107788. Epub 2019 Sep 23. Neuropharmacology. 2020. PMID: 31557492 Free PMC article. Clinical Trial.

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