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Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions.
Maury EA, Sherman MA, Genovese G, Gilgenast TG, Kamath T, Burris SJ, Rajarajan P, Flaherty E, Akbarian S, Chess A, McCarroll SA, Loh PR, Phillips-Cremins JE, Brennand KJ, Macosko EZ, Walters JTR, O'Donovan M, Sullivan P; Psychiatric Genomic Consortium Schizophrenia and CNV workgroup; Brain Somatic Mosaicism Network; Sebat J, Lee EA, Walsh CA. Maury EA, et al. Among authors: akbarian s. Cell Genom. 2023 Jul 6;3(8):100356. doi: 10.1016/j.xgen.2023.100356. eCollection 2023 Aug 9. Cell Genom. 2023. PMID: 37601975 Free PMC article.
The schizophrenia syndrome, circa 2024: What we know and how that informs its nature.
Tandon R, Nasrallah H, Akbarian S, Carpenter WT Jr, DeLisi LE, Gaebel W, Green MF, Gur RE, Heckers S, Kane JM, Malaspina D, Meyer-Lindenberg A, Murray R, Owen M, Smoller JW, Yassin W, Keshavan M. Tandon R, et al. Among authors: akbarian s. Schizophr Res. 2024 Feb;264:1-28. doi: 10.1016/j.schres.2023.11.015. Epub 2023 Dec 12. Schizophr Res. 2024. PMID: 38086109 Review.
SATB2 organizes the 3D genome architecture of cognition in cortical neurons.
Wahl N, Espeso-Gil S, Chietera P, Nagel A, Laighneach A, Morris DW, Rajarajan P, Akbarian S, Dechant G, Apostolova G. Wahl N, et al. Among authors: akbarian s. Mol Cell. 2024 Feb 15;84(4):621-639.e9. doi: 10.1016/j.molcel.2023.12.024. Epub 2024 Jan 19. Mol Cell. 2024. PMID: 38244545
R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription.
LaMarca EA, Saito A, Plaza-Jennings A, Espeso-Gil S, Hellmich A, Fernando MB, Javidfar B, Liao W, Estill M, Townsley K, Florio A, Ethridge JE, Do C, Tycko B, Shen L, Kamiya A, Tsankova NM, Brennand KJ, Akbarian S. LaMarca EA, et al. Among authors: akbarian s. bioRxiv [Preprint]. 2023 Jul 18:2023.07.18.549494. doi: 10.1101/2023.07.18.549494. bioRxiv. 2023. PMID: 37503149 Free PMC article. Preprint.
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy.
Pai B, Tome-Garcia J, Cheng WS, Nudelman G, Beaumont KG, Ghatan S, Panov F, Caballero E, Sarpong K, Marcuse L, Yoo J, Jiang Y, Schaefer A, Akbarian S, Sebra R, Pinto D, Zaslavsky E, Tsankova NM. Pai B, et al. Among authors: akbarian s. Acta Neuropathol Commun. 2022 Oct 23;10(1):149. doi: 10.1186/s40478-022-01453-1. Acta Neuropathol Commun. 2022. PMID: 36274170 Free PMC article.
Correction: High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy.
Pai B, Tome-Garcia J, Cheng WS, Nudelman G, Beaumont KG, Ghatan S, Panov F, Caballero E, Sarpong K, Marcuse L, Yoo J, Jiang Y, Schaefer A, Akbarian S, Sebra R, Pinto D, Zaslavsky E, Tsankova NM. Pai B, et al. Among authors: akbarian s. Acta Neuropathol Commun. 2022 Nov 28;10(1):171. doi: 10.1186/s40478-022-01479-5. Acta Neuropathol Commun. 2022. PMID: 36443832 Free PMC article. No abstract available.
HIV integration in the human brain is linked to microglial activation and 3D genome remodeling.
Plaza-Jennings AL, Valada A, O'Shea C, Iskhakova M, Hu B, Javidfar B, Ben Hutta G, Lambert TY, Murray J, Kassim B, Chandrasekaran S, Chen BK, Morgello S, Won H, Akbarian S. Plaza-Jennings AL, et al. Among authors: akbarian s. Mol Cell. 2022 Dec 15;82(24):4647-4663.e8. doi: 10.1016/j.molcel.2022.11.016. Mol Cell. 2022. PMID: 36525955 Free PMC article.
3D Genome Plasticity in Normal and Diseased Neurodevelopment.
Plaza-Jennings A, Valada A, Akbarian S. Plaza-Jennings A, et al. Among authors: akbarian s. Genes (Basel). 2022 Nov 1;13(11):1999. doi: 10.3390/genes13111999. Genes (Basel). 2022. PMID: 36360237 Free PMC article. Review.
Chromosomal contacts change with age.
Akbarian S, Won H. Akbarian S, et al. Science. 2023 Sep 8;381(6662):1049-1050. doi: 10.1126/science.adk0961. Epub 2023 Sep 7. Science. 2023. PMID: 37676934
271 results