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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV Jr, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Shimazu T, et al. Among authors: akassoglou k. Science. 2013 Jan 11;339(6116):211-4. doi: 10.1126/science.1227166. Epub 2012 Dec 6. Science. 2013. PMID: 23223453 Free PMC article.
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.
Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. Baeza-Raja B, et al. Among authors: akassoglou k. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5838-43. doi: 10.1073/pnas.1103638109. Epub 2012 Mar 28. Proc Natl Acad Sci U S A. 2012. PMID: 22460790 Free PMC article.
Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.
Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. Davalos D, et al. Among authors: akassoglou k. Nat Commun. 2012;3:1227. doi: 10.1038/ncomms2230. Nat Commun. 2012. PMID: 23187627 Free PMC article.
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E. Lim HW, et al. Among authors: akassoglou k. J Exp Med. 2015 May 4;212(5):607-17. doi: 10.1084/jem.20132378. Epub 2015 Apr 27. J Exp Med. 2015. PMID: 25918343 Free PMC article.
Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.
Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Schachtrup C, et al. Among authors: akassoglou k. Nat Neurosci. 2015 Aug;18(8):1077-80. doi: 10.1038/nn.4054. Epub 2015 Jun 29. Nat Neurosci. 2015. PMID: 26120963 Free PMC article.
110 results