Aitken L - Search Results

1

Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems.

Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z, Motykova K, Kubackova J, Bednarikova Z, Janockova J, Jesus C, Cortes L, Pina J, Rostohar D, Serpa C, Soukup O, Aitken L, Hughes RE, Musilek K, Muckova L, Jost P, Chvojkova M, Vales K, Valis M, Chrienova Z, Chalupova K, Kuca K. Nepovimova E, et al. Among authors: aitken l. Bioorg Chem. 2021 Feb;107:104596. doi: 10.1016/j.bioorg.2020.104596. Epub 2020 Dec 28. Bioorg Chem. 2021. PMID: 33421953

2

Mitochondrial β-amyloid in Alzheimer's disease.

Borger E, Aitken L, Muirhead KE, Allen ZE, Ainge JA, Conway SJ, Gunn-Moore FJ. Borger E, et al. Among authors: aitken l. Biochem Soc Trans. 2011 Aug;39(4):868-73. doi: 10.1042/BST0390868. Biochem Soc Trans. 2011. PMID: 21787315

3

Is amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease?

Borger E, Aitken L, Du H, Zhang W, Gunn-Moore FJ, Yan SS. Borger E, et al. Among authors: aitken l. Curr Alzheimer Res. 2013 Jan;10(1):21-9. Curr Alzheimer Res. 2013. PMID: 22742981 Free PMC article. Review.

4

Benzothiazoles - scaffold of interest for CNS targeted drugs.

Hroch L, Aitken L, Benek O, Dolezal M, Kuca K, Gunn-Moore F, Musilek K. Hroch L, et al. Among authors: aitken l. Curr Med Chem. 2015;22(6):730-47. doi: 10.2174/0929867322666141212120631. Curr Med Chem. 2015. PMID: 25515509 Review.

5

A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease.

Benek O, Aitken L, Hroch L, Kuca K, Gunn-Moore F, Musilek K. Benek O, et al. Among authors: aitken l. Curr Med Chem. 2015 Feb 26;22(9):1056 - 1085. doi: 10.2174/0929867322666150114163051. Curr Med Chem. 2015. PMID: 25620098

6

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.

Hroch L, Benek O, Guest P, Aitken L, Soukup O, Janockova J, Musil K, Dohnal V, Dolezal R, Kuca K, Smith TK, Gunn-Moore F, Musilek K. Hroch L, et al. Among authors: aitken l. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3675-8. doi: 10.1016/j.bmcl.2016.05.087. Epub 2016 May 30. Bioorg Med Chem Lett. 2016. PMID: 27287370

7

6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation.

Benek O, Hroch L, Aitken L, Dolezal R, Guest P, Benkova M, Soukup O, Musil K, Kuca K, Smith TK, Gunn-Moore F, Musilek K. Benek O, et al. Among authors: aitken l. Med Chem. 2017 Jan 9. Online ahead of print. Med Chem. 2017. PMID: 28067167

8

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.

Hroch L, Guest P, Benek O, Soukup O, Janockova J, Dolezal R, Kuca K, Aitken L, Smith TK, Gunn-Moore F, Zala D, Ramsay RR, Musilek K. Hroch L, et al. Among authors: aitken l. Bioorg Med Chem. 2017 Feb 1;25(3):1143-1152. doi: 10.1016/j.bmc.2016.12.029. Epub 2016 Dec 27. Bioorg Med Chem. 2017. PMID: 28082069

9

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

Benek O, Hroch L, Aitken L, Gunn-Moore F, Vinklarova L, Kuca K, Perez DI, Perez C, Martinez A, Fisar Z, Musilek K. Benek O, et al. Among authors: aitken l. J Enzyme Inhib Med Chem. 2018 Dec;33(1):665-670. doi: 10.1080/14756366.2018.1445736. J Enzyme Inhib Med Chem. 2018. PMID: 29536773 Free PMC article.

10

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.

Aitken L, Benek O, McKelvie BE, Hughes RE, Hroch L, Schmidt M, Major LL, Vinklarova L, Kuca K, Smith TK, Musilek K, Gunn-Moore FJ. Aitken L, et al. Molecules. 2019 Jul 29;24(15):2757. doi: 10.3390/molecules24152757. Molecules. 2019. PMID: 31362457 Free PMC article.

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