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Page 1
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease.
Ruotsalainen SE, Partanen JJ, Cichonska A, Lin J, Benner C, Surakka I; FinnGen; Reeve MP, Palta P, Salmi M, Jalkanen S, Ahola-Olli A, Palotie A, Salomaa V, Daly MJ, Pirinen M, Ripatti S, Koskela J. Ruotsalainen SE, et al. Eur J Hum Genet. 2021 Feb;29(2):309-324. doi: 10.1038/s41431-020-00730-8. Epub 2020 Oct 27. Eur J Hum Genet. 2021. PMID: 33110245 Free PMC article.
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.
Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT. Ahola-Olli AV, et al. Am J Hum Genet. 2017 Jan 5;100(1):40-50. doi: 10.1016/j.ajhg.2016.11.007. Epub 2016 Dec 15. Am J Hum Genet. 2017. PMID: 27989323 Free PMC article.
Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns.
Sliz E, Kalaoja M, Ahola-Olli A, Raitakari O, Perola M, Salomaa V, Lehtimäki T, Karhu T, Viinamäki H, Salmi M, Santalahti K, Jalkanen S, Jokelainen J, Keinänen-Kiukaanniemi S, Männikkö M, Herzig KH, Järvelin MR, Sebert S, Kettunen J. Sliz E, et al. J Med Genet. 2019 Sep;56(9):607-616. doi: 10.1136/jmedgenet-2018-105965. Epub 2019 Jun 19. J Med Genet. 2019. PMID: 31217265 Free PMC article.
Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts.
Ahola-Olli AV, Mustelin L, Kalimeri M, Kettunen J, Jokelainen J, Auvinen J, Puukka K, Havulinna AS, Lehtimäki T, Kähönen M, Juonala M, Keinänen-Kiukaanniemi S, Salomaa V, Perola M, Järvelin MR, Ala-Korpela M, Raitakari O, Würtz P. Ahola-Olli AV, et al. Diabetologia. 2019 Dec;62(12):2298-2309. doi: 10.1007/s00125-019-05001-w. Epub 2019 Oct 4. Diabetologia. 2019. PMID: 31584131 Free PMC article.
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
Nath AP, Ritchie SC, Grinberg NF, Tang HH, Huang QQ, Teo SM, Ahola-Olli AV, Würtz P, Havulinna AS, Santalahti K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salmi M, Wallace C, Raitakari OT, Salomaa V, Abraham G, Kettunen J, Inouye M. Nath AP, et al. Am J Hum Genet. 2019 Dec 5;105(6):1076-1090. doi: 10.1016/j.ajhg.2019.10.001. Epub 2019 Oct 31. Am J Hum Genet. 2019. PMID: 31679650 Free PMC article.
The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.
Kalaoja M, Corbin LJ, Tan VY, Ahola-Olli AV, Havulinna AS, Santalahti K, Pitkänen N, Lehtimäki T, Lyytikäinen LP, Raitoharju E, Seppälä I, Kähönen M, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Raitakari OT, Kettunen J, Timpson NJ. Kalaoja M, et al. Obesity (Silver Spring). 2021 Feb;29(2):428-437. doi: 10.1002/oby.23060. Obesity (Silver Spring). 2021. PMID: 33491305 Free PMC article.
Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants.
Saarentaus EC, Havulinna AS, Mars N, Ahola-Olli A, Kiiskinen TTJ, Partanen J, Ruotsalainen S, Kurki M, Urpa LM, Chen L, Perola M, Salomaa V, Veijola J, Männikkö M, Hall IM, Pietiläinen O, Kaprio J, Ripatti S, Daly M, Palotie A. Saarentaus EC, et al. Mol Psychiatry. 2021 Sep;26(9):4884-4895. doi: 10.1038/s41380-021-01026-z. Epub 2021 Feb 1. Mol Psychiatry. 2021. PMID: 33526825 Free PMC article.
35 results