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JAK2-V617F and interferon-α induce megakaryocyte-biased stem cells characterized by decreased long-term functionality.
Rao TN, Hansen N, Stetka J, Luque Paz D, Kalmer M, Hilfiker J, Endele M, Ahmed N, Kubovcakova L, Rybarikova M, Hao-Shen H, Geier F, Beisel C, Dirnhofer S, Schroeder T, Brümmendorf TH, Wolf D, Koschmieder S, Skoda RC. Rao TN, et al. Among authors: ahmed n. Blood. 2021 Apr 22;137(16):2139-2151. doi: 10.1182/blood.2020005563. Blood. 2021. PMID: 33667305 Free PMC article.
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.
Hoppe PS, Schwarzfischer M, Loeffler D, Kokkaliaris KD, Hilsenbeck O, Moritz N, Endele M, Filipczyk A, Gambardella A, Ahmed N, Etzrodt M, Coutu DL, Rieger MA, Marr C, Strasser MK, Schauberger B, Burtscher I, Ermakova O, Bürger A, Lickert H, Nerlov C, Theis FJ, Schroeder T. Hoppe PS, et al. Among authors: ahmed n. Nature. 2016 Jul 14;535(7611):299-302. doi: 10.1038/nature18320. Nature. 2016. PMID: 27411635
Inflammatory signals directly instruct PU.1 in HSCs via TNF.
Etzrodt M, Ahmed N, Hoppe PS, Loeffler D, Skylaki S, Hilsenbeck O, Kokkaliaris KD, Kaltenbach HM, Stelling J, Nerlov C, Schroeder T. Etzrodt M, et al. Among authors: ahmed n. Blood. 2019 Feb 21;133(8):816-819. doi: 10.1182/blood-2018-02-832998. Epub 2018 Oct 9. Blood. 2019. PMID: 30301719 Free article.
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.
Chavez JS, Rabe JL, Loeffler D, Higa KC, Hernandez G, Mills TS, Ahmed N, Gessner RL, Ke Z, Idler BM, Niño KE, Kim H, Myers JR, Stevens BM, Davizon-Castillo P, Jordan CT, Nakajima H, Ashton J, Welner RS, Schroeder T, DeGregori J, Pietras EM. Chavez JS, et al. Among authors: ahmed n. J Exp Med. 2021 Jun 7;218(6):e20201169. doi: 10.1084/jem.20201169. J Exp Med. 2021. PMID: 33857288 Free PMC article.
Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms.
Stetka J, Usart M, Kubovcakova L, Rai S, Rao TN, Sutter J, Hao-Shen H, Dirnhofer S, Geier F, Bader MS, Passweg JR, Manolova V, Dürrenberger F, Ahmed N, Schroeder T, Ganz T, Nemeth E, Silvestri L, Nai A, Camaschella C, Skoda RC. Stetka J, et al. Among authors: ahmed n. Blood. 2023 Apr 27;141(17):2127-2140. doi: 10.1182/blood.2022017976. Blood. 2023. PMID: 36758212 Free article.
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Tyrkalska SD, Pérez-Oliva AB, Rodríguez-Ruiz L, Martínez-Morcillo FJ, Alcaraz-Pérez F, Martínez-Navarro FJ, Lachaud C, Ahmed N, Schroeder T, Pardo-Sánchez I, Candel S, López-Muñoz A, Choudhuri A, Rossmann MP, Zon LI, Cayuela ML, García-Moreno D, Mulero V. Tyrkalska SD, et al. Among authors: ahmed n. Immunity. 2019 Jul 16;51(1):50-63.e5. doi: 10.1016/j.immuni.2019.05.005. Epub 2019 Jun 4. Immunity. 2019. PMID: 31174991 Free PMC article.
3,882 results