Ahmed HEA - Search Results

1

A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular docking and orbital analyses.

Khayat MT, Ahmed HEA, Omar AM, Muhammad YA, Mohammad KA, Malebari AM, Khayyat AN, Halawa AH, Abulkhair HS, Al-Karmalawy AA, Almaghrabi M, Alharbi M, Aljahdali AS, El-Agrody AM. Khayat MT, et al. Among authors: ahmed hea. J Biomol Struct Dyn. 2023;41(24):15243-15261. doi: 10.1080/07391102.2023.2188957. Epub 2023 Mar 13. J Biomol Struct Dyn. 2023. PMID: 36914238

2

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor.

Zayed MF, Ihmaid SK, Ahmed HE, El-Adl K, Asiri AM, Omar AM. Zayed MF, et al. Molecules. 2017 Jan 24;22(2):188. doi: 10.3390/molecules22020188. Molecules. 2017. PMID: 28125041 Free PMC article.

3

Rational design, synthesis, pharmacophore modeling, and docking studies for identification of novel potent DNA-PK inhibitors.

Ihmaid S, Ahmed HEA, Al-Sheikh Ali A, Sherif YE, Tarazi HM, Riyadh SM, Zayed MF, Abulkhair HS, Rateb HS. Ihmaid S, et al. Among authors: ahmed hea. Bioorg Chem. 2017 Jun;72:234-247. doi: 10.1016/j.bioorg.2017.04.014. Epub 2017 May 2. Bioorg Chem. 2017. PMID: 28482264

4

Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents.

Ahmed HEA, Ihmaid SK, Omar AM, Shehata AM, Rateb HS, Zayed MF, Ahmed S, Elaasser MM. Ahmed HEA, et al. Among authors: ahmed s. Bioorg Chem. 2018 Feb;76:332-342. doi: 10.1016/j.bioorg.2017.11.019. Epub 2017 Dec 2. Bioorg Chem. 2018. PMID: 29227917

5

Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect.

Ahmed HEA, El-Nassag MAA, Hassan AH, Okasha RM, Ihmaid S, Fouda AM, Afifi TH, Aljuhani A, El-Agrody AM. Ahmed HEA, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1074-1088. doi: 10.1080/14756366.2018.1476503. J Enzyme Inhib Med Chem. 2018. PMID: 29923425 Free PMC article.

6

Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.

Omar AM, Alswah M, Ahmed HEA, Bayoumi AH, El-Gamal KM, El-Morsy A, Ghiaty A, Afifi TH, Sherbiny FF, Mohammed AS, Mansour BA. Omar AM, et al. Among authors: ahmed hea. Bioorg Chem. 2020 Mar;96:103656. doi: 10.1016/j.bioorg.2020.103656. Epub 2020 Feb 10. Bioorg Chem. 2020. PMID: 32062449

7

The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase.

Omar AM, Ihmaid S, Habib EE, Althagfan SS, Ahmed S, Abulkhair HS, Ahmed HEA. Omar AM, et al. Among authors: ahmed hea, ahmed s. Bioorg Chem. 2020 Jun;99:103781. doi: 10.1016/j.bioorg.2020.103781. Epub 2020 Mar 21. Bioorg Chem. 2020. PMID: 32222620

8

Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.

Abulkhair HS, Turky A, Ghiaty A, Ahmed HEA, Bayoumi AH. Abulkhair HS, et al. Among authors: ahmed hea. Bioorg Chem. 2020 Jul;100:103899. doi: 10.1016/j.bioorg.2020.103899. Epub 2020 May 17. Bioorg Chem. 2020. PMID: 32454390

9

Introducing of potent cytotoxic novel 2-(aroylamino)cinnamamide derivatives against colon cancer mediated by dual apoptotic signal activation and oxidative stress.

Omar AM, El-Araby ME, Abdelghany TM, Safo MK, Ahmed MH, Boothello R, Patel BB, Abdel-Bakky MS, Malebari AM, Ahmed HEA, Elhaggar RS. Omar AM, et al. Among authors: ahmed mh, ahmed hea. Bioorg Chem. 2020 Aug;101:103953. doi: 10.1016/j.bioorg.2020.103953. Epub 2020 May 25. Bioorg Chem. 2020. PMID: 32474179

10

Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects.

Omar AM, Bajorath J, Ihmaid S, Mohamed HM, El-Agrody AM, Mora A, El-Araby ME, Ahmed HEA. Omar AM, et al. Among authors: ahmed hea. Bioorg Chem. 2020 Aug;101:103992. doi: 10.1016/j.bioorg.2020.103992. Epub 2020 Jun 2. Bioorg Chem. 2020. PMID: 32554279

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