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Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state.
Bosmans LA, van Tiel CM, Aarts SABM, Willemsen L, Baardman J, van Os BW, Toom MD, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, den Bossche JV, de Winther MMPJ, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E. Bosmans LA, et al. Among authors: ahern dj. Cardiovasc Res. 2023 May 22;119(5):1146-1160. doi: 10.1093/cvr/cvac084. Cardiovasc Res. 2023. PMID: 35587037 Free PMC article.
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.
Cribbs AP, Terlecki-Zaniewicz S, Philpott M, Baardman J, Ahern D, Lindow M, Obad S, Oerum H, Sampey B, Mander PK, Penn H, Wordsworth P, Bowness P, de Winther M, Prinjha RK, Feldmann M, Oppermann U. Cribbs AP, et al. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6056-6066. doi: 10.1073/pnas.1919893117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123118 Free PMC article.
Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.
Weeratunga P, Denney L, Bull JA, Repapi E, Sergeant M, Etherington R, Vuppussetty C, Turner GDH, Clelland C, Woo J, Cross A, Issa F, de Andrea CE, Melero Bermejo I, Sims D, McGowan S, Zurke YX, Ahern DJ, Gamez EC, Whalley J, Richards D, Klenerman P, Monaco C, Udalova IA, Dong T, Antanaviciute A, Ogg G, Knight JC, Byrne HM, Taylor S, Ho LP. Weeratunga P, et al. Among authors: ahern dj. Nat Commun. 2023 Nov 8;14(1):7216. doi: 10.1038/s41467-023-42421-0. Nat Commun. 2023. PMID: 37940670 Free PMC article.
Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Nielsen N, Pascal V, Fasth AE, Sundström Y, Galsgaard ED, Ahern D, Andersen M, Baslund B, Bartels EM, Bliddal H, Feldmann M, Malmström V, Berg L, Spee P, Söderström K. Nielsen N, et al. Immunology. 2014 Aug;142(4):581-93. doi: 10.1111/imm.12271. Immunology. 2014. PMID: 24673109 Free PMC article. Clinical Trial.
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk; COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk, et al. Cell. 2022 Mar 3;185(5):916-938.e58. doi: 10.1016/j.cell.2022.01.012. Epub 2022 Jan 21. Cell. 2022. PMID: 35216673 Free PMC article.
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19.
Kotanidis CP, Xie C, Alexander D, Rodrigues JCL, Burnham K, Mentzer A, O'Connor D, Knight J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou EK, Badi I, Lyasheva M, Shirodaria C, Lumley SF, Constantinides B, Sanderson N, Rodger G, Chau KK, Lodge A, Tsakok M, Gleeson F, Adlam D, Rao P, Indrajeet D, Deshpande A, Bajaj A, Hudson BJ, Srivastava V, Farid S, Krasopoulos G, Sayeed R, Ho LP, Neubauer S, Newby DE, Channon KM, Deanfield J, Antoniades C; COMBAT Consortium; ORFAN investigators. Kotanidis CP, et al. Lancet Digit Health. 2022 Oct;4(10):e705-e716. doi: 10.1016/S2589-7500(22)00132-7. Epub 2022 Aug 26. Lancet Digit Health. 2022. PMID: 36038496 Free PMC article.
27 results