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GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner.
González-Rubio S, López-Sánchez L, Muñoz-Castañeda J, Linares CI, Aguilar-Melero P, Rodríguez-Perálvarez M, Sánchez-Sánchez R, Fernández-Álvarez A, Casado M, Montero-Álvarez JL, Rodríguez-Ariza A, Muntané J, de la Mata M, Ferrín G. González-Rubio S, et al. Among authors: aguilar melero p. Biochem Pharmacol. 2015 Jul 1;96(1):39-51. doi: 10.1016/j.bcp.2015.04.017. Epub 2015 Apr 27. Biochem Pharmacol. 2015. PMID: 25931146
Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes.
González-Rubio S, Linares CI, Bello RI, González R, Ferrín G, Hidalgo AB, Muñoz-Gomariz E, Rodríguez BA, Barrera P, Ranchal I, Durán-Prado M, Aguilar-Melero P, De la Mata M, Muntané J. González-Rubio S, et al. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):165-72. doi: 10.1016/j.taap.2009.10.003. Epub 2009 Oct 23. Toxicol Appl Pharmacol. 2010. PMID: 19837105
Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes.
González-Rubio S, Hidalgo AB, Ferrín G, Bello RI, González R, Gahete MD, Ranchal I, Rodríguez BA, Barrera P, Aguilar-Melero P, Linares CI, Castaño JP, Victor VM, De la Mata M, Muntané J. González-Rubio S, et al. Chem Res Toxicol. 2009 Dec;22(12):1984-91. doi: 10.1021/tx900327t. Chem Res Toxicol. 2009. PMID: 20020783
Targeting hepatoma using nitric oxide donor strategies.
González R, Ferrín G, Aguilar-Melero P, Ranchal I, Linares CI, Bello RI, De la Mata M, Gogvadze V, Bárcena JA, Alamo JM, Orrenius S, Padillo FJ, Zhivotovsky B, Muntané J. González R, et al. Antioxid Redox Signal. 2013 Feb 10;18(5):491-506. doi: 10.1089/ars.2011.4476. Epub 2012 Sep 26. Antioxid Redox Signal. 2013. PMID: 22861189
Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant.
Aguilar-Melero P, Luque A, Machuca MM, Pérez de Obanos MP, Navarrete R, Rodríguez-García IC, Briceño J, Iñiguez M, Ruiz J, Prieto J, de la Mata M, Gomez-Villamandos RJ, Muntane J, López-Cillero P. Aguilar-Melero P, et al. J Surg Res. 2013 May;181(2):e83-91. doi: 10.1016/j.jss.2012.07.046. Epub 2012 Aug 8. J Surg Res. 2013. PMID: 22906559
Sensitivity to anti-Fas is independent of increased cathepsin D activity and adrenodoxin reductase expression occurring in NOS-3 overexpressing HepG2 cells.
Linares CI, Ferrín G, Aguilar-Melero P, González-Rubio S, Rodríguez-Perálvarez M, Sánchez-Aragó M, Chicano-Gálvez E, Cuezva JM, Montero-Álvarez JL, Muntané J, de la Mata M. Linares CI, et al. Biochim Biophys Acta. 2015 May;1853(5):1182-94. doi: 10.1016/j.bbamcr.2015.02.015. Epub 2015 Feb 21. Biochim Biophys Acta. 2015. PMID: 25712867 Free article.
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