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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.
Shapira T, Monreal IA, Dion SP, Buchholz DW, Imbiakha B, Olmstead AD, Jager M, Désilets A, Gao G, Martins M, Vandal T, Thompson CAH, Chin A, Rees WD, Steiner T, Nabi IR, Marsault E, Sahler J, Diel DG, Van de Walle GR, August A, Whittaker GR, Boudreault PL, Leduc R, Aguilar HC, Jean F. Shapira T, et al. Among authors: aguilar hc. Nature. 2022 May;605(7909):340-348. doi: 10.1038/s41586-022-04661-w. Epub 2022 Mar 28. Nature. 2022. PMID: 35344983 Free PMC article.
Finding proteases that make cells go viral.
Aguilar HC, Buchholz DW. Aguilar HC, et al. J Biol Chem. 2020 Aug 14;295(33):11408-11409. doi: 10.1074/jbc.H120.015153. J Biol Chem. 2020. PMID: 32817125 Free PMC article.
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice.
Shapira T, Monreal IA, Dion SP, Jager M, Désilets A, Olmstead AD, Vandal T, Buchholz DW, Imbiakha B, Gao G, Chin A, Rees WD, Steiner T, Nabi IR, Marsault E, Sahler J, August A, Van de Walle G, Whittaker GR, Boudreault PL, Aguilar HC, Leduc R, Jean F. Shapira T, et al. Among authors: aguilar hc. bioRxiv [Preprint]. 2021 May 4:2021.05.03.442520. doi: 10.1101/2021.05.03.442520. bioRxiv. 2021. PMID: 33972944 Free PMC article. Preprint.
Antivirals targeting paramyxovirus membrane fusion.
Contreras EM, Monreal IA, Ruvalcaba M, Ortega V, Aguilar HC. Contreras EM, et al. Among authors: aguilar hc. Curr Opin Virol. 2021 Dec;51:34-47. doi: 10.1016/j.coviro.2021.09.003. Epub 2021 Sep 27. Curr Opin Virol. 2021. PMID: 34592709 Free PMC article. Review.
Ecology, evolution and spillover of coronaviruses from bats.
Ruiz-Aravena M, McKee C, Gamble A, Lunn T, Morris A, Snedden CE, Yinda CK, Port JR, Buchholz DW, Yeo YY, Faust C, Jax E, Dee L, Jones DN, Kessler MK, Falvo C, Crowley D, Bharti N, Brook CE, Aguilar HC, Peel AJ, Restif O, Schountz T, Parrish CR, Gurley ES, Lloyd-Smith JO, Hudson PJ, Munster VJ, Plowright RK. Ruiz-Aravena M, et al. Among authors: aguilar hc. Nat Rev Microbiol. 2022 May;20(5):299-314. doi: 10.1038/s41579-021-00652-2. Epub 2021 Nov 19. Nat Rev Microbiol. 2022. PMID: 34799704 Free PMC article. Review.
90 results