Aguilar A - Search Results

1

The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.

Zhou J, Kryczek I, Li S, Li X, Aguilar A, Wei S, Grove S, Vatan L, Yu J, Yan Y, Liao P, Lin H, Li J, Li G, Du W, Wang W, Lang X, Wang W, Wang S, Zou W. Zhou J, et al. Among authors: aguilar a. Nat Immunol. 2021 Apr;22(4):460-470. doi: 10.1038/s41590-021-00888-3. Epub 2021 Mar 25. Nat Immunol. 2021. PMID: 33767425 Free PMC article.

2

Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Zhou H, et al. Among authors: aguilar a. J Med Chem. 2012 May 24;55(10):4664-82. doi: 10.1021/jm300178u. Epub 2012 May 10. J Med Chem. 2012. PMID: 22448988 Free PMC article.

3

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Zhou H, et al. Among authors: aguilar a. J Med Chem. 2012 Jul 12;55(13):6149-61. doi: 10.1021/jm300608w. Epub 2012 Jul 2. J Med Chem. 2012. PMID: 22747598 Free PMC article.

4

Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.

Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Chen J, et al. Among authors: aguilar a. J Med Chem. 2012 Oct 11;55(19):8502-14. doi: 10.1021/jm3010306. Epub 2012 Oct 2. J Med Chem. 2012. PMID: 23030453 Free PMC article.

5

A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.

Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, Stuckey J, Wang S. Aguilar A, et al. J Med Chem. 2013 Apr 11;56(7):3048-3067. doi: 10.1021/jm4001105. Epub 2013 Mar 22. J Med Chem. 2013. PMID: 23448298 Free PMC article.

6

BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo.

Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, Wang S. Bai L, et al. Among authors: aguilar a. PLoS One. 2014 Jun 5;9(6):e99404. doi: 10.1371/journal.pone.0099404. eCollection 2014. PLoS One. 2014. PMID: 24901320 Free PMC article.

7

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.

Wang S, Sun W, Zhao Y, McEachern D, Meaux I, Barrière C, Stuckey JA, Meagher JL, Bai L, Liu L, Hoffman-Luca CG, Lu J, Shangary S, Yu S, Bernard D, Aguilar A, Dos-Santos O, Besret L, Guerif S, Pannier P, Gorge-Bernat D, Debussche L. Wang S, et al. Among authors: aguilar a. Cancer Res. 2014 Oct 15;74(20):5855-65. doi: 10.1158/0008-5472.CAN-14-0799. Epub 2014 Aug 21. Cancer Res. 2014. PMID: 25145672 Free PMC article.

8

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

Zhao Y, Aguilar A, Bernard D, Wang S. Zhao Y, et al. Among authors: aguilar a. J Med Chem. 2015 Feb 12;58(3):1038-52. doi: 10.1021/jm501092z. Epub 2014 Nov 14. J Med Chem. 2015. PMID: 25396320 Free PMC article. Review.

9

Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.

Aguilar A, Sun W, Liu L, Lu J, McEachern D, Bernard D, Deschamps JR, Wang S. Aguilar A, et al. J Med Chem. 2014 Dec 26;57(24):10486-98. doi: 10.1021/jm501541j. Epub 2014 Dec 12. J Med Chem. 2014. PMID: 25496041 Free PMC article.

10

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.

Wang S, Zhao Y, Aguilar A, Bernard D, Yang CY. Wang S, et al. Among authors: aguilar a. Cold Spring Harb Perspect Med. 2017 May 1;7(5):a026245. doi: 10.1101/cshperspect.a026245. Cold Spring Harb Perspect Med. 2017. PMID: 28270530 Free PMC article. Review.

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