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Sustained Liver HBsAg Loss and Clonal T- and B-Cell Expansion upon Therapeutic DNA Vaccination Require Low HBsAg Levels.
Conceição-Neto N, Pierson W, Vacca M, Beyens M, De Clerck B, Aerts L, Voeten B, De Pooter D, Verschueren L, Dockx K, Vandenberk M, De Troyer E, Verwilt K, Van Hove C, Verslegers M, Bosseler L, Crabbe M, Krishna V, Nájera I, Van Gulck E. Conceição-Neto N, et al. Among authors: aerts l. Vaccines (Basel). 2023 Dec 6;11(12):1825. doi: 10.3390/vaccines11121825. Vaccines (Basel). 2023. PMID: 38140229 Free PMC article.
Determining Recommended Acceptable Intake Limits for N-Nitrosamine Impurities in Pharmaceuticals: Development and Application of the Carcinogenic Potency Categorization Approach (CPCA).
Kruhlak NL, Schmidt M, Froetschl R, Graber S, Haas B, Horne I, Horne S, King ST, Koval IA, Kumaran G, Langenkamp A, McGovern TJ, Peryea T, Sanh A, Ferreira AS, van Aerts L, Vespa A, Whomsley R. Kruhlak NL, et al. Among authors: van aerts l. Regul Toxicol Pharmacol. 2024 May 14:105640. doi: 10.1016/j.yrtph.2024.105640. Online ahead of print. Regul Toxicol Pharmacol. 2024. PMID: 38754805 Free article.
Hybrid atrial fibrillation ablation.
van der Heijden CAJ, Aerts L, Chaldoupi SM, van Cruchten C, Kawczynski M, Heuts S, Bidar E, Luermans JGLM, Maesen B. van der Heijden CAJ, et al. Among authors: aerts l. Ann Cardiothorac Surg. 2024 Jan 30;13(1):54-70. doi: 10.21037/acs-2023-afm-0129. Epub 2023 Dec 13. Ann Cardiothorac Surg. 2024. PMID: 38380145 Free PMC article. Review.
Predicting crystal form stability under real-world conditions.
Firaha D, Liu YM, van de Streek J, Sasikumar K, Dietrich H, Helfferich J, Aerts L, Braun DE, Broo A, DiPasquale AG, Lee AY, Le Meur S, Nilsson Lill SO, Lunsmann WJ, Mattei A, Muglia P, Putra OD, Raoui M, Reutzel-Edens SM, Rome S, Sheikh AY, Tkatchenko A, Woollam GR, Neumann MA. Firaha D, et al. Among authors: aerts l. Nature. 2023 Nov;623(7986):324-328. doi: 10.1038/s41586-023-06587-3. Epub 2023 Nov 8. Nature. 2023. PMID: 37938708 Free PMC article.
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1.
Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PCG, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P. Ruiz de Almodovar C, et al. Among authors: aerts l. Neuron. 2023 Apr 19;111(8):1348. doi: 10.1016/j.neuron.2023.03.029. Neuron. 2023. PMID: 37080170 Free article. No abstract available.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Prior H, Andrews L, Cauvin A, Chien H, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Reid K, Schutte K, Sewell F, Trouba K, Ulrich P, van Aerts L, van Meer P, Weir L. Prior H, et al. Among authors: van aerts l. Regul Toxicol Pharmacol. 2023 Feb;138:105339. doi: 10.1016/j.yrtph.2023.105339. Epub 2023 Jan 14. Regul Toxicol Pharmacol. 2023. PMID: 36649820 Free article. Review.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Chien HT, Prior H, Andrews L, van Aerts L, Cauvin A, Clarke DO, Datta K, Dempster M, Dybdal N, Freebern W, de Haan L, Herzyk D, Hey A, Kissner T, Kronenberg S, Leach MW, Lee D, Schutte K, Sewell F, Trouba K, Ulrich P, Weir L, van Meer P. Chien HT, et al. Among authors: van aerts l. Regul Toxicol Pharmacol. 2023 Feb;138:105329. doi: 10.1016/j.yrtph.2022.105329. Epub 2022 Dec 30. Regul Toxicol Pharmacol. 2023. PMID: 36592682 Free article.
159 results