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Cerebrospinal fluid α-synuclein adds the risk of cognitive decline and is associated with tau pathology among non-demented older adults.
Liu W, Li W, Liu Z, Li Y, Wang X, Guo M, Wang S, Wang S, Li Y, Jia J. Liu W, et al. Alzheimers Res Ther. 2024 May 10;16(1):103. doi: 10.1186/s13195-024-01463-2. Alzheimers Res Ther. 2024. PMID: 38725083 Free PMC article.
METHODS: A total of 331 non-demented individuals were included in the study from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants were divided into two distinct groups based on their alpha-synuclein levels: one with lower levels (alpha-synuclein-L) and …
METHODS: A total of 331 non-demented individuals were included in the study from the Alzheimer's Disease Neuroimaging Initiative (ADNI …
A 3D pseudo-continuous arterial spin labeling study of altered cerebral blood flow correlation networks in mild cognitive impairment and Alzheimer's disease.
Li M, Zhu T, Kang Y, Qi S. Li M, et al. Front Aging Neurosci. 2024 Apr 24;16:1345251. doi: 10.3389/fnagi.2024.1345251. eCollection 2024. Front Aging Neurosci. 2024. PMID: 38721017 Free PMC article.
METHODS: 3D PCASL images of 53 cognitive normal (CN) subjects, 43 subjects with MCI, and 30 subjects with AD were acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Whole-brain CBF maps were calculated using PCASL and proton density-weighted ima …
METHODS: 3D PCASL images of 53 cognitive normal (CN) subjects, 43 subjects with MCI, and 30 subjects with AD were acquired from the Alzheime …
DMA-HPCNet: Dual Multi-level Attention Hybrid Pyramid Convolution Neural Network for Alzheimer's Disease Classification.
Mu S, Shan S, Li L, Jing S, Li R, Zheng C, Cui X. Mu S, et al. IEEE Trans Neural Syst Rehabil Eng. 2024 May 8;PP. doi: 10.1109/TNSRE.2024.3398640. Online ahead of print. IEEE Trans Neural Syst Rehabil Eng. 2024. PMID: 38717874
Our proposed DMA-HPCNet method was evaluated on baseline MRI slices of 443 subjects from the ADNI dataset. Experimental results show that our proposed DMA-HPCNet model performs efficiently in AD-related classification tasks with low computational cost....
Our proposed DMA-HPCNet method was evaluated on baseline MRI slices of 443 subjects from the ADNI dataset. Experimental results show …
Metabolic phenotyping reveals an emerging role of ammonia abnormality in Alzheimer's disease.
Chen T, Pan F, Huang Q, Xie G, Chao X, Wu L, Wang J, Cui L, Sun T, Li M, Wang Y, Guan Y, Zheng X, Ren Z, Guo Y, Wang L, Zhou K, Zhao A, Guo Q, Xie F, Jia W. Chen T, et al. Nat Commun. 2024 May 7;15(1):3796. doi: 10.1038/s41467-024-47897-y. Nat Commun. 2024. PMID: 38714706 Free PMC article.
We validated their performances in eight data sets (total n = 7685) obtained from Alzheimer's Disease Neuroimaging Initiative (ADNI) and Religious Orders Study and Memory and Aging Project (ROSMAP). ...
We validated their performances in eight data sets (total n = 7685) obtained from Alzheimer's Disease Neuroimaging Initiative (ADNI) …
Innovative Multivariable Model Combining MRI Radiomics and Plasma Indexes Predicts Alzheimer's Disease Conversion: Evidence from a 2-Cohort Longitudinal Study.
Yu X, Sun X, Wei M, Deng S, Zhang Q, Guo T, Shao K, Zhang M, Jiang J, Han Y; Alzheimer’s Disease Neuroimaging Initiative. Yu X, et al. Research (Wash D C). 2024 Apr 16;7:0354. doi: 10.34133/research.0354. eCollection 2024. Research (Wash D C). 2024. PMID: 38711474 Free PMC article.
This longitudinal multicentric cohort study included 2 independent cohorts: the Sino Longitudinal Study on Cognitive Decline (SILCODE) project and the Alzheimer Disease Neuroimaging Initiative (ADNI). We collected comprehensive assessments, MRI, plasma samples, and amyloid …
This longitudinal multicentric cohort study included 2 independent cohorts: the Sino Longitudinal Study on Cognitive Decline (SILCODE) proje …
Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease.
Younes K, Smith V, Johns E, Carlson ML, Winer J, He Z, Henderson VW, Greicius MD, Young CB, Mormino EC; Alzheimer's Disease Neuroimaging Initiative Researchers. Younes K, et al. Brain Behav Immun. 2024 May 4:S0889-1591(24)00390-8. doi: 10.1016/j.bbi.2024.05.002. Online ahead of print. Brain Behav Immun. 2024. PMID: 38710339
This cross-sectional study investigated the correlation between temporal tau PET asymmetry and behavior assessed using the neuropsychiatric inventory and composite scores for memory, executive function, and language, using data from the Alzheimer's Disease Neuroimaging Initiative …
This cross-sectional study investigated the correlation between temporal tau PET asymmetry and behavior assessed using the neuropsychiatric …
Predicting Alzheimer's progression in MCI: a DTI-based white matter network model.
Song Q, Peng J, Shu Z, Xu Y, Shao Y, Yu W, Yu L. Song Q, et al. BMC Med Imaging. 2024 May 3;24(1):103. doi: 10.1186/s12880-024-01284-7. BMC Med Imaging. 2024. PMID: 38702626 Free PMC article.
METHODS: This study enrolled 121 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Among them, 36 progressed to AD after four years of follow-up. ...
METHODS: This study enrolled 121 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Among them, 36 progressed …
Unraveling the genetic architecture of blood unfolded p-53 among non-demented elderlies: novel candidate genes for early Alzheimer's disease.
Yaghoobi A, Malekpour SA. Yaghoobi A, et al. BMC Genomics. 2024 May 3;25(1):440. doi: 10.1186/s12864-024-10363-6. BMC Genomics. 2024. PMID: 38702606 Free PMC article.
RESULTS: We performed a blood U-p53 Genome-wide association study (GWAS) on 484 healthy and mild cognitively impaired subjects from the ADNI cohort using 612,843 Single nucleotide polymorphisms (SNPs). ...We validated the candidate genes in an independent brain single-cell …
RESULTS: We performed a blood U-p53 Genome-wide association study (GWAS) on 484 healthy and mild cognitively impaired subjects from the A …
Predicting amyloid-PET and clinical conversion in apolipoprotein E ε3/ε3 non-demented individuals with multidimensional factors.
Xu L, Ren C, Jing C, Wang G, Wei H, Kong M, Ba M; for Alzheimer's Disease Neuroimaging Initiative. Xu L, et al. Eur J Neurosci. 2024 May 2. doi: 10.1111/ejn.16376. Online ahead of print. Eur J Neurosci. 2024. PMID: 38698692
Two hundred and ninety-three non-demented individuals with APOE epsilon3/epsilon3 from ADNI database were divided into Abeta-positron emission tomography (Abeta-PET) positivity (+) and Abeta-PET negativity (-) groups using cut-off value of >1.11. ...
Two hundred and ninety-three non-demented individuals with APOE epsilon3/epsilon3 from ADNI database were divided into Abeta-positron …
U-shaped convolutional transformer GAN with multi-resolution consistency loss for restoring brain functional time-series and dementia diagnosis.
Zuo Q, Li R, Shi B, Hong J, Zhu Y, Chen X, Wu Y, Guo J. Zuo Q, et al. Front Comput Neurosci. 2024 Apr 17;18:1387004. doi: 10.3389/fncom.2024.1387004. eCollection 2024. Front Comput Neurosci. 2024. PMID: 38694950 Free PMC article.
RESULTS: We theoretically tested our model on the public Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, and our experiments demonstrate that the proposed model outperforms existing methods in terms of both quantitative metrics and qualitative assessments. ...
RESULTS: We theoretically tested our model on the public Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, and our experime …
2,974 results