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A Placebo-Controlled, Double-Blind Randomized (Phase IIB) Trial of Oral Administration with HPV16 E7-Expressing Lactobacillus, GLBL101c, for the Treatment of Cervical Intraepithelial Neoplasia Grade 2 (CIN2).
Ikeda Y, Adachi K, Tomio K, Eguchi-Kojima S, Tsuruga T, Uchino-Mori M, Taguchi A, Komatsu A, Nagamatsu T, Oda K, Kawana-Tachikawa A, Uemura Y, Igimi S, Osuga Y, Fujii T, Kawana K. Ikeda Y, et al. Among authors: adachi k. Vaccines (Basel). 2021 Apr 1;9(4):329. doi: 10.3390/vaccines9040329. Vaccines (Basel). 2021. PMID: 33915901 Free PMC article.
Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner.
Taguchi A, Kawana K, Yokoyama T, Adachi K, Yamashita A, Tomio K, Kojima S, Oda K, Fujii T, Kozuma S. Taguchi A, et al. Among authors: adachi k. Vaccine. 2012 Aug 3;30(36):5368-72. doi: 10.1016/j.vaccine.2012.06.027. Epub 2012 Jun 21. Vaccine. 2012. PMID: 22727726
The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN.
Kojima S, Kawana K, Tomio K, Yamashita A, Taguchi A, Miura S, Adachi K, Nagamatsu T, Nagasaka K, Matsumoto Y, Arimoto T, Oda K, Wada-Hiraike O, Yano T, Taketani Y, Fujii T, Schust DJ, Kozuma S. Kojima S, et al. Among authors: adachi k. Am J Reprod Immunol. 2013 Feb;69(2):134-41. doi: 10.1111/aji.12030. Epub 2012 Oct 11. Am J Reprod Immunol. 2013. PMID: 23057776
Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients.
Kawana K, Adachi K, Kojima S, Taguchi A, Tomio K, Yamashita A, Nishida H, Nagasaka K, Arimoto T, Yokoyama T, Wada-Hiraike O, Oda K, Sewaki T, Osuga Y, Fujii T. Kawana K, et al. Among authors: adachi k. Vaccine. 2014 Oct 29;32(47):6233-9. doi: 10.1016/j.vaccine.2014.09.020. Epub 2014 Sep 22. Vaccine. 2014. PMID: 25258102 Clinical Trial.
Intracellular signaling entropy can be a biomarker for predicting the development of cervical intraepithelial neoplasia.
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Ogishima J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T. Sato M, et al. Among authors: adachi k. PLoS One. 2017 Apr 28;12(4):e0176353. doi: 10.1371/journal.pone.0176353. eCollection 2017. PLoS One. 2017. PMID: 28453530 Free PMC article.
CD1d, a sentinel molecule bridging innate and adaptive immunity, is downregulated by the human papillomavirus (HPV) E5 protein: a possible mechanism for immune evasion by HPV.
Miura S, Kawana K, Schust DJ, Fujii T, Yokoyama T, Iwasawa Y, Nagamatsu T, Adachi K, Tomio A, Tomio K, Kojima S, Yasugi T, Kozuma S, Taketani Y. Miura S, et al. Among authors: adachi k. J Virol. 2010 Nov;84(22):11614-23. doi: 10.1128/JVI.01053-10. Epub 2010 Sep 1. J Virol. 2010. PMID: 20810727 Free PMC article.
Characterization of gut-derived intraepithelial lymphocyte (IEL) residing in human papillomavirus (HPV)-infected intraepithelial neoplastic lesions.
Kojima S, Kawana K, Fujii T, Yokoyama T, Miura S, Tomio K, Tomio A, Yamashita A, Adachi K, Sato H, Nagamatsu T, Schust DJ, Kozuma S, Taketani Y. Kojima S, et al. Among authors: adachi k. Am J Reprod Immunol. 2011 Nov;66(5):435-43. doi: 10.1111/j.1600-0897.2011.01041.x. Epub 2011 Jul 12. Am J Reprod Immunol. 2011. PMID: 21749545
2,242 results