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Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria.
Francischetti IM, Oliveira CJ, Ostera GR, Yager SB, Debierre-Grockiego F, Carregaro V, Jaramillo-Gutierrez G, Hume JC, Jiang L, Moretz SE, Lin CK, Ribeiro JM, Long CA, Vickers BK, Schwarz RT, Seydel KB, Iacobelli M, Ackerman HC, Srinivasan P, Gomes RB, Wang X, Monteiro RQ, Kotsyfakis M, Sá-Nunes A, Waisberg M. Francischetti IM, et al. Among authors: ackerman hc. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):786-98. doi: 10.1161/ATVBAHA.111.240291. Epub 2011 Nov 23. Arterioscler Thromb Vasc Biol. 2012. PMID: 22116094 Free PMC article.
Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria.
Francischetti IM, Gordon E, Bizzarro B, Gera N, Andrade BB, Oliveira F, Ma D, Assumpção TC, Ribeiro JM, Pena M, Qi CF, Diouf A, Moretz SE, Long CA, Ackerman HC, Pierce SK, Sá-Nunes A, Waisberg M. Francischetti IM, et al. Among authors: ackerman hc. PLoS One. 2014 Feb 28;9(2):e87140. doi: 10.1371/journal.pone.0087140. eCollection 2014. PLoS One. 2014. PMID: 24586264 Free PMC article.
The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study.
Ackerman H, Ayestaran A, Olola CHO, Jallow M, Agbenyega T, Bojang K, Roberts DJ, Krishna S, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. Ackerman H, et al. Lancet Haematol. 2020 Nov;7(11):e789-e797. doi: 10.1016/S2352-3026(20)30288-X. Lancet Haematol. 2020. PMID: 33091354 Free PMC article.
51 results