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Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Goethals O, Kaptein SJF, Kesteleyn B, Bonfanti JF, Van Wesenbeeck L, Bardiot D, Verschoor EJ, Verstrepen BE, Fagrouch Z, Putnak JR, Kiemel D, Ackaert O, Straetemans R, Lachau-Durand S, Geluykens P, Crabbe M, Thys K, Stoops B, Lenz O, Tambuyzer L, De Meyer S, Dallmeier K, McCracken MK, Gromowski GD, Rutvisuttinunt W, Jarman RG, Karasavvas N, Touret F, Querat G, de Lamballerie X, Chatel-Chaix L, Milligan GN, Beasley DWC, Bourne N, Barrett ADT, Marchand A, Jonckers THM, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Bogers WM, Neyts J, Van Loock M. Goethals O, et al. Among authors: ackaert o. Nature. 2023 Mar;615(7953):678-686. doi: 10.1038/s41586-023-05790-6. Epub 2023 Mar 15. Nature. 2023. PMID: 36922586 Free PMC article.
Efficacy and Safety Exposure-Response Relationships of Apalutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer.
Perez-Ruixo C, Ackaert O, Ouellet D, Chien C, Uemura H, Olmos D, Mainwaring P, Lee JY, Yu MK, Perez-Ruixo JJ, Smith MR, Small EJ. Perez-Ruixo C, et al. Among authors: ackaert o. Clin Cancer Res. 2020 Sep 1;26(17):4460-4467. doi: 10.1158/1078-0432.CCR-20-1041. Epub 2020 Jun 19. Clin Cancer Res. 2020. PMID: 32561663 Free article. Clinical Trial.
Exploring genetic and non-genetic risk factors for delayed graft function, acute and subclinical rejection in renal transplant recipients.
Moes DJ, Press RR, Ackaert O, Ploeger BA, Bemelman FJ, Diack C, Wessels JA, van der Straaten T, Danhof M, Sanders JS, Homan van der Heide JJ, Guchelaar HJ, de Fijter JW. Moes DJ, et al. Among authors: ackaert o. Br J Clin Pharmacol. 2016 Jul;82(1):227-37. doi: 10.1111/bcp.12946. Epub 2016 May 10. Br J Clin Pharmacol. 2016. PMID: 27334415 Free PMC article. Clinical Trial.
Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Healthy Volunteers.
Ackaert O, Vanhoutte F, Verpoorten N, Buelens A, Lachau-Durand S, Lammens L, Hoetelmans R, Van Loock M, Herrera-Taracena G. Ackaert O, et al. Clin Infect Dis. 2023 Sep 18;77(6):857-865. doi: 10.1093/cid/ciad284. Clin Infect Dis. 2023. PMID: 37161721 Free PMC article. Clinical Trial.
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