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Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence.
Segura-Cerda CA, Aceves-Sánchez MJ, Marquina-Castillo B, Mata-Espinoza D, Barrios-Payán J, Vega-Domínguez PJ, Pedroza-Roldán C, Bravo-Madrigal J, Vallejo-Cardona AA, Hernández-Pando R, Flores-Valdez MA. Segura-Cerda CA, et al. Vaccine. 2018 Apr 12;36(16):2069-2078. doi: 10.1016/j.vaccine.2018.03.014. Epub 2018 Mar 15. Vaccine. 2018. PMID: 29550192
BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice.
Pedroza-Roldán C, Marquina-Castillo B, Mata-Espinosa D, Barrios-Payán J, Aceves-Sánchez MJ, Hernández Pando R, Flores-Valdez MA. Pedroza-Roldán C, et al. Tuberculosis (Edinb). 2018 Dec;113:19-25. doi: 10.1016/j.tube.2018.08.012. Epub 2018 Aug 24. Tuberculosis (Edinb). 2018. PMID: 30514503
28 results