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On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.
Cole MA, Abd Jamil AH, Heather LC, Murray AJ, Sutton ER, Slingo M, Sebag-Montefiore L, Tan SC, Aksentijević D, Gildea OS, Stuckey DJ, Yeoh KK, Carr CA, Evans RD, Aasum E, Schofield CJ, Ratcliffe PJ, Neubauer S, Robbins PA, Clarke K. Cole MA, et al. Among authors: abd jamil ah. FASEB J. 2016 Aug;30(8):2684-97. doi: 10.1096/fj.201500094R. Epub 2016 Apr 21. FASEB J. 2016. PMID: 27103577 Free PMC article.
Metabolic adaptation to chronic hypoxia in cardiac mitochondria.
Heather LC, Cole MA, Tan JJ, Ambrose LJ, Pope S, Abd-Jamil AH, Carter EE, Dodd MS, Yeoh KK, Schofield CJ, Clarke K. Heather LC, et al. Among authors: abd jamil ah. Basic Res Cardiol. 2012 May;107(3):268. doi: 10.1007/s00395-012-0268-2. Epub 2012 Apr 27. Basic Res Cardiol. 2012. PMID: 22538979
Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulation.
Ambrose LJ, Abd-Jamil AH, Gomes RS, Carter EE, Carr CA, Clarke K, Heather LC. Ambrose LJ, et al. Among authors: abd jamil ah. J Cardiovasc Pharmacol Ther. 2014 Nov;19(6):574-85. doi: 10.1177/1074248414524480. Epub 2014 Mar 7. J Cardiovasc Pharmacol Ther. 2014. PMID: 24607765