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Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity.
Arch Pharm (Weinheim). 2019 Aug;352(8):e1900002. doi: 10.1002/ardp.201900002. Epub 2019 Jul 29.
Arch Pharm (Weinheim). 2019.
PMID: 31353608
Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking.
Abd El-Aleam RH, George RF, Hassan GS, Abdel-Rahman HM.
Abd El-Aleam RH, et al.
Bioorg Chem. 2020 Jan;94:103411. doi: 10.1016/j.bioorg.2019.103411. Epub 2019 Nov 4.
Bioorg Chem. 2020.
PMID: 31711767
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Bacterial virulence factors: a target for heterocyclic compounds to combat bacterial resistance.
Abd El-Aleam RH, George RF, Georgey HH, Abdel-Rahman HM.
Abd El-Aleam RH, et al.
RSC Adv. 2021 Nov 19;11(58):36459-36482. doi: 10.1039/d1ra06238g. eCollection 2021 Nov 10.
RSC Adv. 2021.
PMID: 35494393
Free PMC article.
Review.
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Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation.
Abd El-Aleam RH, Sayed AM, Taha MN, George RF, Georgey HH, Abdel-Rahman HM.
Abd El-Aleam RH, et al.
Eur J Med Chem. 2022 Nov 5;241:114629. doi: 10.1016/j.ejmech.2022.114629. Epub 2022 Aug 5.
Eur J Med Chem. 2022.
PMID: 35961070
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Norlobaridone Inhibits Quorum Sensing-Dependent Biofilm Formation and Some Virulence Factors in Pseudomonas aeruginosa by Disrupting Its Transcriptional Activator Protein LasR Dimerization.
Soltane R, Alasiri A, Taha MN, Abd El-Aleam RH, Alghamdi KS, Ghareeb MA, Keshek DE, Cardoso SM, Sayed AM.
Soltane R, et al. Among authors: abd el aleam rh.
Biomolecules. 2023 Oct 24;13(11):1573. doi: 10.3390/biom13111573.
Biomolecules. 2023.
PMID: 38002255
Free PMC article.
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Bakuchiol inhibits Pseudomonas aeruginosa's quorum sensing-dependent biofilm formation by selectively inhibiting its transcriptional activator protein LasR.
Alasiri A, Soltane R, Taha MN, Abd El-Aleam RH, Alshehri F, Sayed AM.
Alasiri A, et al. Among authors: abd el aleam rh.
Int J Biol Macromol. 2024 Jan;255:128025. doi: 10.1016/j.ijbiomac.2023.128025. Epub 2023 Nov 16.
Int J Biol Macromol. 2024.
PMID: 37979739
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