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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure.
Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L. Zwirner S, et al. Among authors: ab e. Cell. 2024 Mar 28;187(7):1666-1684.e26. doi: 10.1016/j.cell.2024.02.023. Epub 2024 Mar 14. Cell. 2024. PMID: 38490194 Free PMC article. Clinical Trial.
Fragment-derived modulators of an industrial β-glucosidase.
Makraki E, Darby JF, Carneiro MG, Firth JD, Heyam A, Ab E, O'Brien P, Siegal G, Hubbard RE. Makraki E, et al. Among authors: ab e. Biochem J. 2020 Nov 27;477(22):4383-4395. doi: 10.1042/BCJ20200507. Biochem J. 2020. PMID: 33111951 Free PMC article.
NMR in target driven drug discovery: why not?
Keiffer S, Carneiro MG, Hollander J, Kobayashi M, Pogoryelev D, Ab E, Theisgen S, Müller G, Siegal G. Keiffer S, et al. Among authors: ab e. J Biomol NMR. 2020 Nov;74(10-11):521-529. doi: 10.1007/s10858-020-00343-9. Epub 2020 Sep 8. J Biomol NMR. 2020. PMID: 32901320 Free PMC article.
Dynamics of Ligand Binding to a Rigid Glycosidase*.
Ben Bdira F, Waudby CA, Volkov AN, Schröder SP, Ab E, Codée JDC, Overkleeft HS, Aerts JMFG, van Ingen H, Ubbink M. Ben Bdira F, et al. Among authors: ab e. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20508-20514. doi: 10.1002/anie.202003236. Epub 2020 Sep 3. Angew Chem Int Ed Engl. 2020. PMID: 32533782 Free PMC article.
NMR in structure-based drug design.
Carneiro MG, Ab E, Theisgen S, Siegal G. Carneiro MG, et al. Among authors: ab e. Essays Biochem. 2017 Nov 8;61(5):485-493. doi: 10.1042/EBC20170037. Print 2017 Nov 8. Essays Biochem. 2017. PMID: 29118095 Review.
38 results