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Galactosaminogalactan activates the inflammasome to provide host protection.
Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latgé JP, Kanneganti TD. Briard B, et al. Nature. 2020 Dec;588(7839):688-692. doi: 10.1038/s41586-020-2996-z. Epub 2020 Dec 2. Nature. 2020. PMID: 33268895 Free PMC article.
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Samir P, Kesavardhana S, Patmore DM, Gingras S, Malireddi RKS, Karki R, Guy CS, Briard B, Place DE, Bhattacharya A, Sharma BR, Nourse A, King SV, Pitre A, Burton AR, Pelletier S, Gilbertson RJ, Kanneganti TD. Samir P, et al. Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11. Nature. 2019. PMID: 31511697 Free PMC article.